Seroatlas · Human Serome Atlas

TTC16

Tetratricopeptide repeat protein 16

Also known as: FLJ32780, TTC16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEE8
Gene: TTC16
Ensembl: ENSG00000167094
Chromosome: 9
Canonical length: 873 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for TTC16 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

873 residues, UniProt reviewed canonical sequence.

>Q8NEE8|TTC16
     1  MTDSDEDALK VDQGPSRDIP KPWVIPAPKG ILQHIFGTSH VFQSICDVKP KVTGLTVPLK
    61  VREYYSRGQQ CLEQADWETA VLLFSRALHL DPQLVDFYAL RAEAYLQLCD FSSAAQNLRR
   121  AYSLQQDNCK HLERLTFVLY LQGQCLFEQC AFLDALNVFS HAAELQPEKP CFRYRCMACL
   181  LALKQHQACL TLITNELKQD TTNADVYIFR ARLYNFLQKP HLCYRDLHSA LLLNPKHPQA
   241  RMLLQKMVAQ AQQARQDAGI LAVQGKLQHA LQRINRAIEN NPLDPSLFLF RGTMYRRLQE
   301  FDGAVEDFLK VLDMVTEDQE DMVRQAQRQL LLTYNDFAVH CYRQGAYQEG VLLLNKALRD
   361  EQQEKGLYIN RGDCFFQLGN LAFAEADYQQ ALALSPQDEG ANTRMGLLQE KMGFCEQRRK
   421  QFQKAENHFS TAIRHNPQKA QYYLYRAKSR QLLQNIFGAR QDVATVLLLN PKQPKLSLLM
   481  TNLFPGMSVE EVLSTQIAHL ARLQLEQMVE GSLQAGSPQG IVGMLKRHEL ERQKALALQH
   541  SWKQGEPLIA TSEELKATPE IPQVKPGSSE GEAEAPEEEE EKEKEKKEEK KSELIPSKVA
   601  SLSDSYLDQT SSASSMSFRT TGTSETEMSA ICQEYRSTSA TAVTFSDSSL LKTQSSDSGN
   661  NREALSHGPR KIKATQGQRQ SLSKTEPTQS QRRNSSKTKA TIHKRNSSKT KATQSQRRNS
   721  SKTRATQGQG QSSSKTEATQ GQRQSSSEIE ATQGPRQEPS KTKTTRSPRQ RPRKVKAARG
   781  RSWRPSKVDA TQGRSRGLLR SSTKTEAFYD SNWSLSKTEY AQGQGQRSSK AEGAQGKSQG
   841  MSSTSSKAES TWGPSPSLSK TEVDQDLTYY EAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
fallopian tube: 6.5 nTPM
choroid plexus: 1.1 nTPM
lung: 0.7 nTPM
lymph node: 0.3 nTPM
basal ganglia: 0.2 nTPM

Single-cell type

late spermatids: 427 nCPM
early spermatids: 117 nCPM
late primary spermatocytes: 61 nCPM
respiratory ciliated cells: 61 nCPM
fallopian tube ciliated cells: 30 nCPM
epididymal efferent duct ciliated cells: 13 nCPM

Immune cell

gdT-cell: 1.6 nTPM
naive CD8 T-cell: 1.5 nTPM
memory CD8 T-cell: 1.1 nTPM
MAIT T-cell: 1 nTPM
total PBMC: 0.7 nTPM
memory CD4 T-cell: 0.5 nTPM

Brain region

midbrain: 1.4 nTPM
choroid plexus: 1 nTPM
medulla oblongata: 0.8 nTPM
spinal cord: 0.6 nTPM
pons: 0.4 nTPM
thalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC16 as an antibody target. Whether an autoantibody or antibody against TTC16 could matter depends on whether native TTC16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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