Seroatlas · Human Serome Atlas

TTC14

Tetratricopeptide repeat protein 14

Also known as: FLJ00166, KIAA1980, TTC14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96N46
Gene: TTC14
Ensembl: ENSG00000163728
Chromosome: 3
Canonical length: 770 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

770 residues, UniProt reviewed canonical sequence.

>Q96N46|TTC14
     1  MDRDLLRQSL NCHGSSLLSL LRSEQQDNPH FRSLLGSAAE PARGPPPQHP LQGRKEKRVD
    61  NIEIQKFISK KADLLFALSW KSDAPATSEI NEDSEDHYAI MPPLEQFMEI PSMDRRELFF
   121  RDIERGDIVI GRISSIREFG FFMVLICLGS GIMRDIAHLE ITALCPLRDV PSHSNHGDPL
   181  SYYQTGDIIR AGIKDIDRYH EKLAVSLYSS SLPPHLSGIK LGVISSEELP LYYRRSVELN
   241  SNSLESYENV MQSSLGFVNP GVVEFLLEKL GIDESNPPSL MRGLQSKNFS EDDFASALRK
   301  KQSASWALKC VKIGVDYFKV GRHVDAMNEY NKALEIDKQN VEALVARGAL YATKGSLNKA
   361  IEDFELALEN CPTHRNARKY LCQTLVERGG QLEEEEKFLN AESYYKKALA LDETFKDAED
   421  ALQKLHKYMQ KSLELREKQA EKEEKQKTKK IETSAEKLRK LLKEEKRLKK KRRKSTSSSS
   481  VSSADESVSS SSSSSSSGHK RHKKHKRNRS ESSRSSRRHS SRASSNQIDQ NRKDECYPVP
   541  ANTSASFLNH KQEVEKLLGK QDRLQYEKTQ IKEKDRCPLS SSSLEIPDDF GGRSEDPRDF
   601  YNSYKTQAGS SKTEKPYKSE RHFSSRRNSS DSFCRNSEDK IYGYRRFEKD IEGRKEHYRR
   661  WEPGSVRHST SPASSEYSWK SVEKYKKYAH SGSRDFSRHE QRYRLNTNQG EYEREDNYGE
   721  DIKTEVPEED ALSSKEHSES SVKKNLPQNL LNIFNQIAEF EKEKGNKSKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

retina: 63 nTPM
pituitary gland: 54 nTPM
ovary: 53 nTPM
thyroid gland: 46 nTPM
epididymis: 41 nTPM
lymph node: 39 nTPM

Single-cell type

pituicytes/fscs: 252 nCPM
somatotrophs: 244 nCPM
sertoli cells: 230 nCPM
pituitary stem cells: 229 nCPM
podocytes: 229 nCPM
neutrophil progenitors: 211 nCPM

Immune cell

basophil: 24 nTPM
plasmacytoid DC: 18 nTPM
memory B-cell: 15 nTPM
non-classical monocyte: 15 nTPM
NK-cell: 14 nTPM
naive CD4 T-cell: 13 nTPM

Brain region

choroid plexus: 70 nTPM
white matter: 61 nTPM
cerebral cortex: 59 nTPM
hippocampal formation: 53 nTPM
medulla oblongata: 51 nTPM
amygdala: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

nucleic acid binding

Protein domainsUniProt · Pfam · InterPro

S1 domain
Tetratricopeptide-like helical domain superfamily
Nucleic acid-binding, OB-fold
Tetratricopeptide repeat
TPR repeat
Tetratricopeptide repeat protein 14

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC14 as an antibody target. Whether an autoantibody or antibody against TTC14 could matter depends on whether native TTC14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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