Seroatlas · Human Serome Atlas

TTC13

Tetratricopeptide repeat protein 13

Also known as: FLJ22584, TTC13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NBP0
Gene
TTC13
Ensembl
ENSG00000143643
Chromosome
1
Canonical length
860 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for TTC13 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

860 residues, UniProt reviewed canonical sequence.

>Q8NBP0|TTC13
     1  MAPAGCCCCC CFWGGAVAAA GAARRVLLLL LLGVLSAGLR PGALATEHYS PLSLLKQELQ
    61  HRQQQEAPAG GGGCSPQSGD WGDQYSAECG ESSFLNFHDS DCEPKGSSPC DSLLSLNTEK
   121  ILSQAKSIAE QKRFPFATDN DSTNEELAIA YVLIGSGLYD EAIRHFSTML QEEPDLVSAI
   181  YGRGIAYGKK GLHDIKNAEL ALFELSRVIT LEPDRPEVFE QRAEILSPLG RINEAVNDLT
   241  KAIQLQPSAR LYRHRGTLYF ISEDYATAHE DFQQSLELNK NQPIAMLYKG LTFFHRGLLK
   301  EAIESFKEAL KQKVDFIDAY KSLGQAYREL GNFEAATESF QKALLLNQNH VQTLQLRGMM
   361  LYHHGSLQEA LKNFKRCLQL EPYNEVCQYM KGLSHVAMGQ FYEGIKAQTK VMLNDPLPGQ
   421  KASPEYLKVK YLREYSRYLH AHLDTPLTEY NIDVDLPGSF KDHWAKNLPF LIEDYEEQPG
   481  LQPHIKDVLH QNFESYKPEV QELICVADRL GSLMQYETPG FLPNKRIHRA MGLAALEVMQ
   541  AVQRTWTNSK VRMNGKTRLM QWRDMFDIAV KWRRIADPDQ PVLWLDQMPA RSLSRGFNNH
   601  INLIRGQVIN MRYLEYFEKI LHFIKDRILV YHGANNPKGL LEVREALEKV HKVEDLLPIM
   661  KQFNTKTKDG FTVNTKVPSL KDQGKEYDGF TITITGDKVG NILFSVETQT TEERTQLYHA
   721  EIDALYKDLT AKGKVLILSS EFGEADAVCN LILSLVYYFY NLMPLSRGSS VIAYSVIVGA
   781  LMASGKEVAG KIPKGKLVDF EAMTAPGSEA FSKVAKSWMN LKSISPSYKT LPSVSETFPT
   841  LRSMIEVLNT DSSPRCLKKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 20 nTPM
  • lymph node: 18 nTPM
  • rectum: 15 nTPM
  • tonsil: 14 nTPM
  • stomach: 12 nTPM
  • small intestine: 12 nTPM

Single-cell type

  • microglia: 103 nCPM
  • brain inhibitory neurons: 99 nCPM
  • gonadotrophs: 95 nCPM
  • brain excitatory neurons: 87 nCPM
  • pdcs: 83 nCPM
  • nk-cells: 82 nCPM

Immune cell

  • NK-cell: 7.9 nTPM
  • myeloid DC: 7.7 nTPM
  • gdT-cell: 6.6 nTPM
  • basophil: 5.8 nTPM
  • classical monocyte: 5.5 nTPM
  • non-classical monocyte: 5.4 nTPM

Brain region

  • basal ganglia: 21 nTPM
  • white matter: 21 nTPM
  • hypothalamus: 20 nTPM
  • cerebellum: 17 nTPM
  • cerebral cortex: 17 nTPM
  • spinal cord: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0
gnomAD missense Z
2.55
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC13 as an antibody target. Whether an autoantibody or antibody against TTC13 could matter depends on whether native TTC13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTC13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...