Seroatlas · Human Serome Atlas

TTC12

Tetratricopeptide repeat protein 12

Also known as: FLJ13859, FLJ20535, TPARM, TTC12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H892
Gene: TTC12
Ensembl: ENSG00000149292
Chromosome: 11
Canonical length: 705 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nuclear membrane,Plasma membrane,Cytosol

OverviewNCBI Gene

Involved in axonemal dynein complex assembly and sperm axoneme assembly. Located in several cellular components, including centrosome; cytosol; and nuclear membrane. Implicated in acute lymphoblastic leukemia; alcohol dependence; drug dependence (multiple); nicotine dependence; and primary ciliary dyskinesia 45. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

705 residues, UniProt reviewed canonical sequence.

>Q9H892|TTC12
     1  MDADKEKDLQ KFLKNVDEIS NLIQEMNSDD PVVQQKAVLE TEKRLLLMEE DQEEDECRTT
    61  LNKTMISPPQ TAMKSAEEIN SEAFLASVEK DAKERAKRRR ENKVLADALK EKGNEAFAEG
   121  NYETAILRYS EGLEKLKDMK VLYTNRAQAY MKLEDYEKAL VDCEWALKCD EKCTKAYFHM
   181  GKANLALKNY SVSRECYKKI LEINPKLQTQ VKGYLNQVDL QEKADLQEKE AHELLDSGKN
   241  TAVTTKNLLE TLSKPDQIPL FYAGGIEILT EMINECTEQT LFRMHNGFSI ISDNEVIRRC
   301  FSTAGNDAVE EMVCVSVLKL WQAVCSRNEE NQRVLVIHHD RARLLAALLS SKVLAIRQQS
   361  FALLLHLAQT ESGRSLIINH LDLTRLLEAL VSFLDFSDKE ANTAMGLFTD LALEERFQVW
   421  FQANLPGVLP ALTGVLKTDP KVSSSSALCQ CIAIMGNLSA EPTTRRHMAA CEEFGDGCLS
   481  LLARCEEDVD LFREVIYTLL GLMMNLCLQA PFVSEVWAVE VSRRCLSLLN SQDGGILTRA
   541  AGVLSRTLSS SLKIVEEALR AGVVKKMMKF LKTGGETASR YAIKILAICT NSYHEAREEV
   601  IRLDKKLSVM MKLLSSEDEV LVGNAALCLG NCMEVPNVAS SLLKTDLLQV LLKLAGSDTQ
   661  KTAVQVNAGI ALGKLCTAEP RFAAQLRKLH GLEILNSTMK YISDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

testis: 49 nTPM
parathyroid gland: 23 nTPM
choroid plexus: 18 nTPM
fallopian tube: 17 nTPM
thyroid gland: 15 nTPM
pituitary gland: 13 nTPM

Single-cell type

late spermatids: 304 nCPM
late primary spermatocytes: 219 nCPM
ependymal cells: 166 nCPM
early spermatids: 158 nCPM
respiratory ciliated cells: 138 nCPM
thyrotrophs: 123 nCPM

Immune cell

naive B-cell: 3.3 nTPM
MAIT T-cell: 2.6 nTPM
naive CD4 T-cell: 2.6 nTPM
naive CD8 T-cell: 2.5 nTPM
memory B-cell: 2.3 nTPM
memory CD4 T-cell: 2.2 nTPM

Brain region

choroid plexus: 32 nTPM
medulla oblongata: 15 nTPM
midbrain: 13 nTPM
white matter: 11 nTPM
hypothalamus: 11 nTPM
pons: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TTC12.

Disease | AllUniProt

Conditions TTC12 is implicated in, by any mechanism.

Ciliary dyskinesia, primary, 45 (CILD45) MIM:618801

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 175 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Tetratricopeptide-like helical domain superfamily
Armadillo-type fold
Tetratricopeptide repeat
Tetratricopeptide repeat
Tetratricopeptide repeat
Tetratricopeptide repeat protein 12

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC12 as an antibody target. Whether an autoantibody or antibody against TTC12 could matter depends on whether native TTC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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