Seroatlas · Human Serome Atlas

TSTD3

Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3

Also known as: TSTD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H0UI37
Gene
TSTD3
Ensembl
ENSG00000279170
Chromosome
6
Canonical length
97 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for TSTD3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

97 residues, UniProt reviewed canonical sequence.

>H0UI37|TSTD3
     1  MKIEKCGWSE GLTSIKGNCH NFYTAISKDV TYKELKNLLN SKNIMLIDVR EIWEILEYQK
    61  IPESINVPLD EVGEALQMNP RDFKEKYNEV KPSKSDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSTD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
3.7 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 3.7 nTPM
  • parathyroid gland: 3 nTPM
  • prostate: 2.4 nTPM
  • blood vessel: 2 nTPM
  • pituitary gland: 2 nTPM
  • skeletal muscle: 1.9 nTPM

Single-cell type

  • cardiomyocytes: 461 nCPM
  • epicardial cells: 312 nCPM
  • myonuclei: 247 nCPM
  • thyrotrophs: 234 nCPM
  • adipocytes: 206 nCPM
  • lactotrophs: 203 nCPM

Immune cell

  • naive B-cell: 1.6 nTPM
  • basophil: 1.5 nTPM
  • NK-cell: 1.4 nTPM
  • eosinophil: 1.1 nTPM
  • neutrophil: 1 nTPM
  • memory B-cell: 0.8 nTPM

Brain region

  • cerebellum: 12 nTPM
  • white matter: 9.7 nTPM
  • medulla oblongata: 7.6 nTPM
  • basal ganglia: 7.3 nTPM
  • pons: 7.3 nTPM
  • cerebral cortex: 7.1 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSTD3 as an antibody target. Whether an autoantibody or antibody against TSTD3 could matter depends on whether native TSTD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSTD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSTD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TSTD3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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