Seroatlas · Human Serome Atlas

TSTD2

Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

Also known as: C9orf97, PP4189, TSTD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T7W7
Gene: TSTD2
Ensembl: ENSG00000136925
Chromosome: 9
Canonical length: 516 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable transferase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

516 residues, UniProt reviewed canonical sequence.

>Q5T7W7|TSTD2
     1  MPSSTSPDQG DDLENCILRF SDLDLKDMSL INPSSSLKAE LDGSTKKKYS FAKKKAFALF
    61  VKTKEVPTKR SFECKEKLWK CCRQLFTDQT SIHRHVATQH ADEIYHQTAS ILKQLAVTLS
   121  TSKSLSSADE KNPLKECLPH SHDVSAWLPD ISCFNPDELI SGQGSEEGEV LLYYCYHDLE
   181  DPQWICAWQT ALCQHLHLTG KIRIAAEGIN GTVGGSKLAT RLYVEVMLSF PLFKDDLCKD
   241  DFKTSKGGAH CFPELRVGVF EEIVPMGISP KKISYKKPGI HLSPGEFHKE VEKFLSQANQ
   301  EQSDTILLDC RNFYESKIGR FQGCLAPDIR KFSYFPSYVD KNLELFREKR VLMYCTGGIR
   361  CERGSAYLKA KGVCKEVFQL KGGIHKYLEE FPDGFYKGKL FVFDERYALS YNSDVVSECS
   421  YCGARWDQYK LCSTPQCRQL VLTCPACQGQ GFTACCVTCQ DKGSRKVSGP MQDSFKEECE
   481  CTARRPRIPR ELLQHVRQPV SPEPGPDADE DGPVLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSTD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

tongue: 12 nTPM
pancreas: 9.7 nTPM
thyroid gland: 9.7 nTPM
retina: 9.6 nTPM
parathyroid gland: 9.5 nTPM
skeletal muscle: 9.3 nTPM

Single-cell type

epicardial cells: 250 nCPM
cardiomyocytes: 104 nCPM
pituicytes/fscs: 88 nCPM
myonuclei: 87 nCPM
retinal ganglion cells: 77 nCPM
thymic myoid cells: 72 nCPM

Immune cell

NK-cell: 8.6 nTPM
MAIT T-cell: 7.3 nTPM
memory CD8 T-cell: 5.4 nTPM
intermediate monocyte: 5 nTPM
myeloid DC: 4.8 nTPM
naive CD4 T-cell: 4.8 nTPM

Brain region

white matter: 11 nTPM
midbrain: 8.6 nTPM
spinal cord: 8.4 nTPM
basal ganglia: 8.1 nTPM
hypothalamus: 8.1 nTPM
pons: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Rhodanese-like domain
Rhodanese-like domain superfamily
Rhodanese-like domain
tRNA uridine(34) hydroxylase
Rhodanase, C-terminal
tRNA uridine(34) hydroxylase, N-terminal
TSTD2, N-terminal domain
Rhodanase C-terminal
UPF0176 acylphosphatase like domain
TSTD2 protein N-terminal domain

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSTD2 as an antibody target. Whether an autoantibody or antibody against TSTD2 could matter depends on whether native TSTD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSTD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSTD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...