TSTD1
Thiosulfate:glutathione sulfurtransferase
Also known as: KAT, TSTD1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NFU3
- Gene
- TSTD1
- Ensembl
- ENSG00000215845
- Chromosome
- 1
- Canonical length
- 115 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol,Cytoplasmic bodies
OverviewNCBI Gene
Predicted to enable thiosulfate-thiol sulfurtransferase activity. Predicted to be involved in sulfide oxidation, using sulfide:quinone oxidoreductase. Located in cytoplasmic ribonucleoprotein granule and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>Q8NFU3|TSTD1
1 MAGAPTVSLP ELRSLLASGR ARLFDVRSRE EAAAGTIPGA LNIPVSELES ALQMEPAAFQ
61 ALYSAEKPKL EDEHLVFFCQ MGKRGLQATQ LARSLGYTGA RNYAGAYREW LEKESLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TSTD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 165 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 165 nTPM
- parathyroid gland: 157 nTPM
- kidney: 141 nTPM
- thyroid gland: 140 nTPM
- pituitary gland: 119 nTPM
- prostate: 102 nTPM
Single-cell type
- fallopian tube ciliated cells: 482 nCPM
- epididymal principal cells: 437 nCPM
- esophageal apical cells: 429 nCPM
- colonocytes: 378 nCPM
- respiratory ciliated cells: 361 nCPM
- breast secretory cells: 354 nCPM
Immune cell
- memory B-cell: 533 nTPM
- naive B-cell: 508 nTPM
- basophil: 440 nTPM
- T-reg: 412 nTPM
- eosinophil: 359 nTPM
- neutrophil: 340 nTPM
Brain region
- choroid plexus: 36 nTPM
- basal ganglia: 28 nTPM
- cerebral cortex: 28 nTPM
- hypothalamus: 21 nTPM
- hippocampal formation: 20 nTPM
- white matter: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.98
- gnomAD pLI
- 0.38
- gnomAD missense Z
- 0.82
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- using sulfide:quinone oxidoreductase
- sulfide oxidation
Molecular functions
- thiosulfate-thiol sulfurtransferase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Rhodanese-like domain
- Rhodanese-like domain superfamily
- Rhodanese-like domain
- Thiosulfate:glutathione sulfurtransferase, mammalian
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TSTD1 as an antibody target. Whether an autoantibody or antibody against TSTD1 could matter depends on whether native TSTD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TSTD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TSTD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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