TST

Protein identityUniProt · HPA

UniProt accession

Q16762

Gene

TST

Ensembl

ENSG00000128311

Chromosome

22

Canonical length

297 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q16762|TST
     1  MVHQVLYRAL VSTKWLAESI RTGKLGPGLR VLDASWYSPG TREARKEYLE RHVPGASFFD
    61  IEECRDTASP YEMMLPSEAG FAEYVGRLGI SNHTHVVVYD GEHLGSFYAP RVWWMFRVFG
   121  HRTVSVLNGG FRNWLKEGHP VTSEPSRPEP AVFKATLDRS LLKTYEQVLE NLESKRFQLV
   181  DSRSQGRFLG TEPEPDAVGL DSGHIRGAVN MPFMDFLTED GFEKGPEELR ALFQTKKVDL
   241  SQPLIATCRK GVTACHVALA AYLCGKPDVA VYDGSWSEWF RRAPPESRVS QGKSEKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TST can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

556 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.48

gnomAD pLI

0

gnomAD missense Z

0.59

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cyanate catabolic process
• epithelial cell differentiation
• rRNA import into mitochondrion
• sulfur amino acid catabolic process
• rRNA transport

Molecular functions

• 3-mercaptopyruvate sulfurtransferase activity
• 5S rRNA binding
• thiosulfate-cyanide sulfurtransferase activity

Cellular components

• extracellular space
• mitochondrial matrix
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Thiosulphate sulfurtransferase, conserved site
• Rhodanese-like domain
• Rhodanese-like domain superfamily
• Sulfurtransferase TST/MPST-like
• Rhodanese-like domain

KeywordsUniProt

• Acetylation
• Glycoprotein
• Mitochondrion
• Phosphoprotein
• Repeat
• RNA-binding
• Transferase

InteractionsUniProt · HPA

Protein binding partners of TST in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ETHE1