Seroatlas · Human Serome Atlas

TSSC4

U5 small nuclear ribonucleoprotein TSSC4

Also known as: TSSC4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5U2
Gene
TSSC4
Ensembl
ENSG00000184281
Chromosome
11
Canonical length
329 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q9Y5U2|TSSC4
     1  MAEAGTGEPS PSVEGEHGTE YDTLPSDTVS LSDSDSDLSL PGGAEVEALS PMGLPGEEDS
    61  GPDEPPSPPS GLLPATVQPF HLRGMSSTFS QRSRDIFDCL EGAARRAPSS VAHTSMSDNG
   121  GFKRPLAPSG RSPVEGLGRA HRSPASPRVP PVPDYVAHPE RWTKYSLEDV TEVSEQSNQA
   181  TALAFLGSQS LAAPTDCVSS FNQDPSSCGE GRVIFTKPVR GVEARHERKR VLGKVGEPGR
   241  GGLGNPATDR GEGPVELAHL AGPGSPEAEE WGSHHGGLQE VEALSGSVHS GSVPGLPPVE
   301  TVGFHGSRKR SRDHFRNKSS SPEDPGAEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSSC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • testis: 70 nTPM
  • skeletal muscle: 62 nTPM
  • liver: 49 nTPM
  • colon: 43 nTPM
  • endometrium: 42 nTPM
  • bone marrow: 40 nTPM

Single-cell type

  • late spermatids: 295 nCPM
  • late primary spermatocytes: 210 nCPM
  • syncytiotrophoblasts: 95 nCPM
  • esophageal suprabasal cells: 92 nCPM
  • esophageal apical cells: 91 nCPM
  • early primary spermatocytes: 84 nCPM

Immune cell

  • basophil: 106 nTPM
  • naive B-cell: 88 nTPM
  • T-reg: 75 nTPM
  • NK-cell: 71 nTPM
  • eosinophil: 70 nTPM
  • MAIT T-cell: 69 nTPM

Brain region

  • thalamus: 32 nTPM
  • white matter: 32 nTPM
  • medulla oblongata: 30 nTPM
  • basal ganglia: 30 nTPM
  • midbrain: 30 nTPM
  • cerebellum: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.72
gnomAD pLI
0.04
gnomAD missense Z
-0.65
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Tumour suppressing sub-chromosomal transferable candidate 4
  • Tumour suppressing sub-chromosomal transferable candidate 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSSC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSSC4 as an antibody target. Whether an autoantibody or antibody against TSSC4 could matter depends on whether native TSSC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSSC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSSC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TSSC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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