Seroatlas · Human Serome Atlas

TSR3

18S rRNA aminocarboxypropyltransferase

Also known as: C16orf42, MGC24381, TSR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJK0
Gene: TSR3
Ensembl: ENSG00000007520
Chromosome: 16
Canonical length: 312 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables rRNA small subunit aminocarboxypropyltransferase activity. Involved in enzyme-directed rRNA pseudouridine synthesis. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q9UJK0|TSR3
     1  MGRRRAARGP GAEGGRPRHL PTRSLEAFAE EVGAALQASV EPGAADGEGG PGPAALPCTL
    61  AMWELGHCDP RRCTGRKLAR LGLVRCLRLG HRFGGLVLSP VGKQYASPAD RQLVAQSGVA
   121  VIDCSWARLD ETPFGKMRGS HLRLLPYLVA ANPVNYGRPY RLSCVEAFAA TFCIVGFPDL
   181  AVILLRKFKW GKGFLDLNRQ LLDKYAACGS PEEVLQAEQE FLANAKESPQ EEEIDPFDVD
   241  SGREFGNPNR PVASTRLPSD TDDSDASEDP GPGAERGGAS SSCCEEEQTQ GRGAEARAPA
   301  EVWKGIKKRQ RD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 81 nTPM
heart muscle: 71 nTPM
amygdala: 66 nTPM
midbrain: 65 nTPM
cerebral cortex: 64 nTPM
basal ganglia: 64 nTPM

Single-cell type

esophageal basal cells: 97 nCPM
esophageal suprabasal cells: 91 nCPM
breast lactating cells: 75 nCPM
epididymal principal cells: 69 nCPM
hepatocytes: 64 nCPM
fallopian tube ciliated cells: 64 nCPM

Immune cell

basophil: 14 nTPM
eosinophil: 12 nTPM
neutrophil: 11 nTPM
naive B-cell: 10 nTPM
memory B-cell: 7.4 nTPM
naive CD4 T-cell: 6.3 nTPM

Brain region

medulla oblongata: 63 nTPM
midbrain: 59 nTPM
thalamus: 58 nTPM
basal ganglia: 58 nTPM
spinal cord: 56 nTPM
cerebellum: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: -0.5
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

S-adenosyl-L-methionine binding
transferase activity
rRNA small subunit aminocarboxypropyltransferase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

RNase L inhibitor RLI-like, possible metal-binding domain
Possible Fer4-like domain in RNase L inhibitor, RLI
16S/18S rRNA aminocarboxypropyltransferase Tsr3, C-terminal
16S/18S rRNA aminocarboxypropyltransferase Tsr3
Ribosome biogenesis protein, C-terminal

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSR3 as an antibody target. Whether an autoantibody or antibody against TSR3 could matter depends on whether native TSR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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