Seroatlas · Human Serome Atlas

TSPYL6

Testis-specific Y-encoded-like protein 6

Also known as: TSYL6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N831
Gene: TSPYL6
Ensembl: ENSG00000178021
Chromosome: 2
Canonical length: 410 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in nucleosome assembly. Predicted to be active in chromatin and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>Q8N831|TSPYL6
     1  MSLPESPHSP ATLDYALEDP HQGQRSREKS KATEVMADMF DGRLEPIVFP PPRLPEEGVA
    61  PQDPADGGHT FHILVDAGRS HGAIKAGQEV TPPPAEGLEA ASASLTTDGS LKNGFPGEET
   121  HGLGGEKALE TCGAGRSESE VIAEGKAEDV KPEECAMFSA PVDEKPGGEE MDVAEENRAI
   181  DEVNREAGPG PGPGPLNVGL HLNPLESIQL ELDSVNAEAD RALLQVERRF GQIHEYYLEQ
   241  RNDIIRNIPG FWVTAFRHHP QLSAMIRGQD AEMLSYLTNL EVKELRHPRT GCKFKFFFQR
   301  NPYFRNKLIV KVYEVRSFGQ VVSFSTLIMW RRGHGPQSFI HRNRHVICSF FTWFSDHSLP
   361  ESDRIAQIIK EDLWSNPLQY YLLGEDAHRA RRRLVREPVE IPRPFGFQCG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPYL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
choroid plexus: 0.1 nTPM
hypothalamus: 0.1 nTPM

Single-cell type

early primary spermatocytes: 29 nCPM
differentiating spermatogonia: 21 nCPM
undifferentiated spermatogonia: 20 nCPM
late primary spermatocytes: 19 nCPM
cardiomyocytes: 12 nCPM
epicardial cells: 6.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 4.9 nTPM
cerebellum: 4.4 nTPM
white matter: 4.4 nTPM
pons: 4.3 nTPM
thalamus: 4.2 nTPM
medulla oblongata: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.71
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nucleosome assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPYL6 as an antibody target. Whether an autoantibody or antibody against TSPYL6 could matter depends on whether native TSPYL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPYL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSPYL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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