Seroatlas · Human Serome Atlas

TSPY26P

Putative testis-specific Y-encoded-like protein 3

Also known as: TSY26_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H489
Gene: TSPY26P
Canonical length: 355 aa

OverviewNCBI Gene

No narrative summary is available for TSPY26P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>Q9H489|TSPY26P
     1  MADKRAGTPE AAARPPPGLA REGDARTVPA ARAREAGGRG SLHPAAGPGT AFPSPGRGEA
    61  ASTATTPSLE NGRVRDEAPE TCGAEGLGTR AGASEKAEDA NKEEGAIFKK EPAEEVEKQQ
   121  EGEEKQEVAA EAQEGPRLLN LGALIVDPLE AIQWEAEAVS AQADRAYLPL ERRFGRMHRL
   181  YLARRSFIIQ NIPGFWVTAF LNHPQLSAMI SPRDEDMLCY LMNLEVRELR HSRTGCKFKF
   241  RFWSNPYFQN KVIVKEYECR ASGRVVSIAT RIRWHWGQEP PALVHRNRDT VRSFFSWFSQ
   301  HSLPEADRVA QIIKDDLWPN PLQYYLLGDR PCRARGGLAR WPTETPSRPY GFQSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPY26P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nucleosome assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPY26P as an antibody target. Whether an autoantibody or antibody against TSPY26P could matter depends on whether native TSPY26P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPY26P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSPY26P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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