TSPO2
Translocator protein 2
Also known as: BZRPL1, dJ34B21.2, TSPO2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5TGU0
- Gene
- TSPO2
- Ensembl
- ENSG00000112212
- Chromosome
- 6
- Canonical length
- 170 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Plasma membrane
- Quaternary structure
- Homotetramer
OverviewNCBI Gene
Enables 5-aminolevulinic acid transmembrane transporter activity. Involved in 5-aminolevulinic acid import across plasma membrane. Located in organelle membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
170 residues, UniProt reviewed canonical sequence.
>Q5TGU0|TSPO2
1 MRLQGAIFVL LPHLGPILVW LFTRDHMSGW CEGPRMLSWC PFYKVLLLVQ TAIYSVVGYA
61 SYLVWKDLGG GLGWPLALPL GLYAVQLTIS WTVLVLFFTV HNPGLALLHL LLLYGLVVST
121 ALIWHPINKL AALLLLPYLA WLTVTSALTY HLWRDSLCPV HQPQPTEKSDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TSPO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 5
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 47 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 47 nTPM
- spleen: 1.2 nTPM
- duodenum: 1.1 nTPM
- placenta: 1.1 nTPM
- small intestine: 0.7 nTPM
- gallbladder: 0.6 nTPM
Single-cell type
- erythrocytes: 62 nCPM
- erythrocyte progenitors: 32 nCPM
- cholangiocytes: 2 nCPM
- enterocytes: 1.8 nCPM
- foveolar cells: 1.5 nCPM
- neuroendocrine cells: 0.8 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 5.4 nTPM
- medulla oblongata: 4.2 nTPM
- cerebral cortex: 4 nTPM
- basal ganglia: 3.6 nTPM
- pons: 3.6 nTPM
- thalamus: 3.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.61
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.55
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- enucleate erythrocyte differentiation
- import across plasma membrane
- intracellular cholesterol transport
- lipid droplet organization
- 5-aminolevulinic acid import across plasma membrane
Molecular functions
- cholesterol binding
- 5-aminolevulinic acid transmembrane transporter activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TSPO2 as an antibody target. Whether an autoantibody or antibody against TSPO2 could matter depends on whether native TSPO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TSPO2 is annotated at the cell surface, where native TSPO2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TSPO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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