TSPAN9
Tetraspanin-9
Also known as: NET-5, TSN9_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75954
- Gene
- TSPAN9
- Ensembl
- ENSG00000011105
- Chromosome
- 12
- Canonical length
- 239 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm,Golgi apparatus,Cytosol
OverviewNCBI Gene
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Nov 2009]
Canonical amino-acid sequenceUniProt
239 residues, UniProt reviewed canonical sequence.
>O75954|TSPAN9
1 MARGCLCCLK YMMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS LSAANLVIAI
61 GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LVILLAELIL LILFFVYMDK VNENAKKDLK
121 EGLLLYHTEN NVGLKNAWNI IQAEMRCCGV TDYTDWYPVL GENTVPDRCC MENSQGCGRN
181 ATTPLWRTGC YEKVKMWFDD NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDALocalizationUniProt · AlphaFold · HPA
Whether an antibody against TSPAN9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 149 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 149 nTPM
- heart muscle: 121 nTPM
- placenta: 55 nTPM
- liver: 54 nTPM
- kidney: 44 nTPM
- lung: 36 nTPM
Single-cell type
- retinal bipolar cells: 391 nCPM
- distal convoluted tubule cells: 377 nCPM
- proximal tubule cells: 342 nCPM
- renal collecting duct intercalated cells: 287 nCPM
- platelets: 285 nCPM
- renal connecting tubule cells: 276 nCPM
Immune cell
- total PBMC: 1.2 nTPM
- gdT-cell: 0.4 nTPM
- memory CD8 T-cell: 0.3 nTPM
- naive CD8 T-cell: 0.2 nTPM
- neutrophil: 0.2 nTPM
- naive CD4 T-cell: 0.1 nTPM
Brain region
- cerebellum: 199 nTPM
- thalamus: 33 nTPM
- pons: 27 nTPM
- cerebral cortex: 25 nTPM
- midbrain: 24 nTPM
- hypothalamus: 23 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.52
- gnomAD pLI
- 0.66
- gnomAD missense Z
- 1.38
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- collagen-activated tyrosine kinase receptor signaling pathway
- mitocytosis
- neutrophil homeostasis
- platelet aggregation
- regulation of mitochondrial membrane potential
- receptor diffusion trapping
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TSPAN9 as an antibody target. Whether an autoantibody or antibody against TSPAN9 could matter depends on whether native TSPAN9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TSPAN9 is annotated at the cell surface, where native TSPAN9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TSPAN9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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