Seroatlas · Human Serome Atlas

TSPAN6

Tetraspanin-6

Also known as: T245, TM4SF6, TSN6_HUMAN, TSPAN-6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43657
Gene: TSPAN6
Ensembl: ENSG00000000003
Chromosome: X
Canonical length: 245 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoli fibrillar center,Cell Junctions,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>O43657|TSPAN6
     1  MASPSRRLQT KPVITCFKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF SLLNEKATNV
    61  PFVLIATGTV IILLGTFGCF ATCRASAWML KLYAMFLTLV FLVELVAAIV GFVFRHEIKN
   121  SFKNNYEKAL KQYNSTGDYR SHAVDKIQNT LHCCGVTDYR DWTDTNYYSE KGFPKSCCKL
   181  EDCTPQRDAD KVNNEGCFIK VMTIIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN
   241  QYEIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 73 nTPM
testis: 66 nTPM
liver: 66 nTPM
salivary gland: 50 nTPM
ovary: 38 nTPM
fallopian tube: 37 nTPM

Single-cell type

late spermatids: 3,513 nCPM
esophageal apical cells: 1,281 nCPM
early spermatids: 463 nCPM
fallopian tube ciliated cells: 278 nCPM
breast lactating cells: 150 nCPM
late primary spermatocytes: 138 nCPM

Immune cell

naive CD4 T-cell: 2.1 nTPM
naive CD8 T-cell: 1.2 nTPM
MAIT T-cell: 1.1 nTPM
memory CD4 T-cell: 0.8 nTPM
gdT-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM

Brain region

choroid plexus: 48 nTPM
white matter: 16 nTPM
hypothalamus: 12 nTPM
midbrain: 12 nTPM
spinal cord: 11 nTPM
medulla oblongata: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.07
gnomAD missense Z: 0.59
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN6 as an antibody target. Whether an autoantibody or antibody against TSPAN6 could matter depends on whether native TSPAN6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN6 is annotated at the cell surface, where native TSPAN6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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