Seroatlas · Human Serome Atlas

TSPAN5

Tetraspanin-5

Also known as: NET-4, TM4SF9, TSN5_HUMAN, Tspan-5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62079
Gene: TSPAN5
Ensembl: ENSG00000168785
Chromosome: 4
Canonical length: 268 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

268 residues, UniProt reviewed canonical sequence.

>P62079|TSPAN5
     1  MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI SSITDLGGFD
    61  PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI IFFLELTAGV LAFVFKDWIK
   121  DQLYFFINNN IRAYRDDIDL QNLIDFTQEY WQCCGAFGAD DWNLNIYFNC TDSNASRERC
   181  GVPFSCCTKD PAEDVINTQC GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF
   241  IGIALLQIFG ICLAQNLVSD IEAVRASW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 67 nTPM
ovary: 45 nTPM
cerebral cortex: 43 nTPM
epididymis: 28 nTPM
retina: 26 nTPM
spinal cord: 25 nTPM

Single-cell type

lymphatic endothelial cells: 621 nCPM
oligodendrocytes: 573 nCPM
brain excitatory neurons: 479 nCPM
gonadotrophs: 426 nCPM
ocular epithelial cells: 394 nCPM
esophageal apical cells: 380 nCPM

Immune cell

T-reg: 6.1 nTPM
memory CD4 T-cell: 4.7 nTPM
memory CD8 T-cell: 4.7 nTPM
NK-cell: 3.9 nTPM
MAIT T-cell: 3.6 nTPM
gdT-cell: 3.3 nTPM

Brain region

cerebellum: 123 nTPM
white matter: 93 nTPM
cerebral cortex: 82 nTPM
hippocampal formation: 79 nTPM
basal ganglia: 67 nTPM
thalamus: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.91
gnomAD missense Z: 2.08
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

enzyme binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSPAN5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ADAM10

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN5 as an antibody target. Whether an autoantibody or antibody against TSPAN5 could matter depends on whether native TSPAN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN5 is annotated at the cell surface, where native TSPAN5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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