Seroatlas · Human Serome Atlas

TSPAN33

Tetraspanin-33

Also known as: MGC50844, Penumbra, TSN33_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UF1
Gene: TSPAN33
Ensembl: ENSG00000158457
Chromosome: 7
Canonical length: 283 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Microtubules
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables enzyme binding activity. Involved in pore complex assembly; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. Part of pore complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>Q86UF1|TSPAN33
     1  MARRPRAPAA SGEEFSFVSP LVKYLLFFFN MLFWVISMVM VAVGVYARLM KHAEAALACL
    61  AVDPAILLIV VGVLMFLLTF CGCIGSLREN ICLLQTFSLC LTAVFLLQLA AGILGFVFSD
   121  KARGKVSEII NNAIVHYRDD LDLQNLIDFG QKKFSCCGGI SYKDWSQNMY FNCSEDNPSR
   181  ERCSVPYSCC LPTPDQAVIN TMCGQGMQAF DYLEASKVIY TNGCIDKLVN WIHSNLFLLG
   241  GVALGLAIPQ LVGILLSQIL VNQIKDQIKL QLYNQQHRAD PWY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

kidney: 47 nTPM
salivary gland: 18 nTPM
lymph node: 15 nTPM
tonsil: 14 nTPM
liver: 13 nTPM
pancreas: 11 nTPM

Single-cell type

platelets: 988 nCPM
megakaryocytes: 148 nCPM
cdc: 125 nCPM
epididymal principal cells: 70 nCPM
b-cells: 49 nCPM
epididymal efferent duct absorptive cells: 49 nCPM

Immune cell

naive B-cell: 1.3 nTPM
memory B-cell: 1.1 nTPM
intermediate monocyte: 0.7 nTPM
myeloid DC: 0.6 nTPM
total PBMC: 0.4 nTPM
classical monocyte: 0.3 nTPM

Brain region

hypothalamus: 27 nTPM
midbrain: 26 nTPM
pons: 23 nTPM
spinal cord: 21 nTPM
medulla oblongata: 20 nTPM
white matter: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 1.36
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

enzyme binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSPAN33 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ADAM10

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN33 as an antibody target. Whether an autoantibody or antibody against TSPAN33 could matter depends on whether native TSPAN33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN33 is annotated at the cell surface, where native TSPAN33 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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