Seroatlas · Human Serome Atlas

TSPAN3

Tetraspanin-3

Also known as: TM4-A, TM4SF8, TSN3_HUMAN, TSPAN-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60637
Gene: TSPAN3
Ensembl: ENSG00000140391
Chromosome: 15
Canonical length: 253 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>O60637|TSPAN3
     1  MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT LIPAVVIIAV
    61  GALLFIIGLI GCCATIRESR CGLATFVIIL LLVFVTEVVV VVLGYVYRAK VENEVDRSIQ
   121  KVYKTYNGTN PDAASRAIDY VQRQLHCCGI HNYSDWENTD WFKETKNQSV PLSCCRETAS
   181  NCNGSLAHPS DLYAEGCEAL VVKKLQEIMM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD
   241  PAYELLITGG TYA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 409 nTPM

Expression across tissuesHPA

Tissue

epididymis: 409 nTPM
skeletal muscle: 402 nTPM
choroid plexus: 395 nTPM
retina: 388 nTPM
rectum: 363 nTPM
tongue: 350 nTPM

Single-cell type

fallopian tube ciliated cells: 478 nCPM
colonocytes: 472 nCPM
müller glia: 422 nCPM
alveolar cells type 2: 421 nCPM
alveolar cells type 1: 375 nCPM
goblet cells: 340 nCPM

Immune cell

naive B-cell: 490 nTPM
memory B-cell: 483 nTPM
plasmacytoid DC: 314 nTPM
myeloid DC: 99 nTPM
total PBMC: 95 nTPM
non-classical monocyte: 77 nTPM

Brain region

hypothalamus: 328 nTPM
choroid plexus: 308 nTPM
thalamus: 300 nTPM
white matter: 285 nTPM
midbrain: 268 nTPM
spinal cord: 261 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.06
gnomAD missense Z: 1.81
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN3 as an antibody target. Whether an autoantibody or antibody against TSPAN3 could matter depends on whether native TSPAN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN3 is annotated at the cell surface, where native TSPAN3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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