Seroatlas · Human Serome Atlas

TSPAN19

Tetraspanin-19

Also known as: TSN19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C672
Gene
TSPAN19
Ensembl
ENSG00000231738
Chromosome
12
Canonical length
248 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>P0C672|TSPAN19
     1  MLRNNKTIII KYFLNLINGA FLVLGLLFMG FGAWLLLDRN NFLTAFDENN HFIVPISQIL
    61  IGMGSSTVLF CLLGYIGIHN EIRWLLIVYA VLITWTFAVQ VVLSAFIITK KEEVQQLWHD
   121  KIDFVISEYG SKDKPEDITK WTILNALQKT LQCCGQHNYT DWIKNKNKEN SGQVPCSCTK
   181  STLRKWFCDE PLNATYLEGC ENKISAWYNV NVLTLIGINF GLLTSEVFQV SLTVCFFKNI
   241  KNIIHAEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
4.1 nTPM

Expression across tissuesHPA

Tissue

  • testis: 4.1 nTPM
  • retina: 4 nTPM
  • lung: 2.5 nTPM
  • choroid plexus: 2.3 nTPM
  • pituitary gland: 1.8 nTPM
  • hypothalamus: 1.5 nTPM

Single-cell type

  • respiratory ciliated cells: 447 nCPM
  • late primary spermatocytes: 84 nCPM
  • early spermatids: 74 nCPM
  • ependymal cells: 13 nCPM
  • rod photoreceptor cells: 13 nCPM
  • lactotrophs: 8.9 nCPM

Immune cell

  • neutrophil: 1.4 nTPM
  • basophil: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • eosinophil: 0.2 nTPM
  • gdT-cell: 0.2 nTPM

Brain region

  • cerebellum: 7.9 nTPM
  • medulla oblongata: 6.2 nTPM
  • choroid plexus: 5.9 nTPM
  • white matter: 5.9 nTPM
  • cerebral cortex: 5.5 nTPM
  • pons: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0
gnomAD missense Z
0.11
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN19 as an antibody target. Whether an autoantibody or antibody against TSPAN19 could matter depends on whether native TSPAN19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN19 is annotated at the cell surface, where native TSPAN19 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TSPAN19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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