Seroatlas · Human Serome Atlas

TSPAN17

Tetraspanin-17

Also known as: FBX23, FBXO23, TM4SF17, TSN17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FV3
Gene: TSPAN17
Ensembl: ENSG00000048140
Chromosome: 5
Canonical length: 270 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the transmembrane 4 superfamily. It is characterized by four tetraspanin transmembrane segments. The function of this gene has not yet been determined. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q96FV3|TSPAN17
     1  MPGKHQHFQE PEVGCCGKYF LFGFNIVFWV LGALFLAIGL WAWGEKGVLS NISALTDLGG
    61  LDPVWLFVVV GGVMSVLGFA GCIGALRENT FLLKFFSVFL GLIFFLELAT GILAFVFKDW
   121  IRDQLNLFIN NNVKAYRDDI DLQNLIDFAQ EYWSCCGARG PNDWNLNIYF NCTDLNPSRE
   181  RCGVPFSCCV RDPAEDVLNT QCGYDVRLKL ELEQQGFIHT KGCVGQFEKW LQDNLIVVAG
   241  VFMGIALLQI FGICLAQNLV SDIKAVKANW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 55 nTPM
skeletal muscle: 39 nTPM
adrenal gland: 38 nTPM
heart muscle: 27 nTPM
cerebral cortex: 25 nTPM
pancreas: 25 nTPM

Single-cell type

erythrocyte progenitors: 73 nCPM
esophageal apical cells: 44 nCPM
esophageal suprabasal cells: 40 nCPM
esophageal basal cells: 32 nCPM
foveolar cells: 28 nCPM
enterocytes: 27 nCPM

Immune cell

T-reg: 7.5 nTPM
memory CD8 T-cell: 6.2 nTPM
non-classical monocyte: 3.9 nTPM
gdT-cell: 3.8 nTPM
MAIT T-cell: 3.1 nTPM
NK-cell: 3 nTPM

Brain region

cerebral cortex: 30 nTPM
basal ganglia: 26 nTPM
amygdala: 23 nTPM
hippocampal formation: 23 nTPM
thalamus: 20 nTPM
choroid plexus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

enzyme binding

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSPAN17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ADAM10

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN17 as an antibody target. Whether an autoantibody or antibody against TSPAN17 could matter depends on whether native TSPAN17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN17 is annotated at the cell surface, where native TSPAN17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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