TSPAN16
Tetraspanin-16
Also known as: TM-8, TM4-B, TM4SF16, TSN16_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UKR8
- Gene
- TSPAN16
- Ensembl
- ENSG00000130167
- Chromosome
- 19
- Canonical length
- 245 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Plasma membrane
OverviewNCBI Gene
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein might couple to signal transduction pathways and possibly modulate cellular activation and adhesion in haemopoietic and neural tissue. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Canonical amino-acid sequenceUniProt
245 residues, UniProt reviewed canonical sequence.
>Q9UKR8|TSPAN16
1 MAEIHTPYSS LKKLLSLLNG FVAVSGIILV GLGIGGKCGG ASLTNVLGLS SAYLLHVGNL
61 CLVMGCITVL LGCAGWYGAT KESRGTLLFC ILSMVIVLIM EVTAATVVLL FFPIVGDVAL
121 EHTFVTLRKN YRGYNEPDDY STQWNLVMEK LKCCGVNNYT DFSGSSFEMT TGHTYPRSCC
181 KSIGSVSCDG RDVSPNVIHQ KGCFHKLLKI TKTQSFTLSG SSLGAAVIQR WGSRYVAQAG
241 LELLALocalizationUniProt · AlphaFold · HPA
Whether an antibody against TSPAN16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 125 nTPM
Expression across tissuesHPA
Tissue
- testis: 125 nTPM
- bone marrow: 4.8 nTPM
- amygdala: 0.5 nTPM
- hippocampal formation: 0.5 nTPM
- basal ganglia: 0.2 nTPM
- cerebral cortex: 0.2 nTPM
Single-cell type
- late spermatids: 8,553 nCPM
- early spermatids: 1,157 nCPM
- late primary spermatocytes: 137 nCPM
- neutrophils: 84 nCPM
- neutrophil progenitors: 17 nCPM
- sertoli cells: 13 nCPM
Immune cell
- neutrophil: 38 nTPM
- eosinophil: 19 nTPM
- basophil: 17 nTPM
- classical monocyte: 2.2 nTPM
- intermediate monocyte: 0.9 nTPM
- myeloid DC: 0.5 nTPM
Brain region
- hippocampal formation: 2 nTPM
- cerebellum: 1.8 nTPM
- cerebral cortex: 1.8 nTPM
- hypothalamus: 1.7 nTPM
- amygdala: 1.6 nTPM
- basal ganglia: 1.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.48
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.42
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TSPAN16 as an antibody target. Whether an autoantibody or antibody against TSPAN16 could matter depends on whether native TSPAN16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TSPAN16 is annotated at the cell surface, where native TSPAN16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TSPAN16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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