TSPAN14
Tetraspanin-14
Also known as: DC-TM4F2, MGC11352, TM4SF14, TSN14_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NG11
- Gene
- TSPAN14
- Ensembl
- ENSG00000108219
- Chromosome
- 10
- Canonical length
- 270 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Vesicles
OverviewNCBI Gene
Enables enzyme binding activity. Involved in positive regulation of Notch signaling pathway; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
270 residues, UniProt reviewed canonical sequence.
>Q8NG11|TSPAN14
1 MHYYRYSNAK VSCWYKYLLF SYNIIFWLAG VVFLGVGLWA WSEKGVLSDL TKVTRMHGID
61 PVVLVLMVGV VMFTLGFAGC VGALRENICL LNFFCGTIVL IFFLELAVAV LAFLFQDWVR
121 DRFREFFESN IKSYRDDIDL QNLIDSLQKA NQCCGAYGPE DWDLNVYFNC SGASYSREKC
181 GVPFSCCVPD PAQKVVNTQC GYDVRIQLKS KWDESIFTKG CIQALESWLP RNIYIVAGVF
241 IAISLLQIFG IFLARTLISD IEAVKAGHHFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TSPAN14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 85 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 85 nTPM
- esophagus: 82 nTPM
- placenta: 71 nTPM
- breast: 71 nTPM
- skin: 65 nTPM
- lung: 62 nTPM
Single-cell type
- neutrophils: 323 nCPM
- esophageal apical cells: 311 nCPM
- kupffer cells: 299 nCPM
- prostatic hillock cells: 246 nCPM
- urothelial cells: 209 nCPM
- ocular epithelial cells: 196 nCPM
Immune cell
- non-classical monocyte: 161 nTPM
- intermediate monocyte: 95 nTPM
- NK-cell: 90 nTPM
- gdT-cell: 86 nTPM
- total PBMC: 80 nTPM
- naive CD4 T-cell: 78 nTPM
Brain region
- thalamus: 63 nTPM
- midbrain: 60 nTPM
- white matter: 58 nTPM
- medulla oblongata: 58 nTPM
- spinal cord: 57 nTPM
- amygdala: 53 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.29
- gnomAD pLI
- 0.98
- gnomAD missense Z
- 2.21
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- positive regulation of Notch signaling pathway
- protein localization to plasma membrane
- protein maturation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TSPAN14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TSPAN14 as an antibody target. Whether an autoantibody or antibody against TSPAN14 could matter depends on whether native TSPAN14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TSPAN14 is annotated at the cell surface, where native TSPAN14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TSPAN14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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