Seroatlas · Human Serome Atlas

TSPAN13

Tetraspanin-13

Also known as: NET-6, TM4SF13, TSN13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95857
Gene: TSPAN13
Ensembl: ENSG00000106537
Chromosome: 7
Canonical length: 204 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>O95857|TSPAN13
     1  MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI AVGIFLFLIA
    61  LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN QEQQGQLLEV GWNNTASARN
   121  DIQRNLNCCG FRSVNPNDTC LASCVKSDHS CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE
   181  ILGVWLTYRY RNQKDPRANP SAFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 175 nTPM

Expression across tissuesHPA

Tissue

lung: 175 nTPM
salivary gland: 158 nTPM
stomach: 102 nTPM
rectum: 94 nTPM
pancreas: 90 nTPM
pituitary gland: 88 nTPM

Single-cell type

alveolar cells type 1: 513 nCPM
conjunctival goblet cells: 414 nCPM
gastric progenitor cells: 382 nCPM
goblet cells: 377 nCPM
cytotrophoblasts: 376 nCPM
pdcs: 291 nCPM

Immune cell

plasmacytoid DC: 232 nTPM
naive B-cell: 100 nTPM
memory B-cell: 48 nTPM
total PBMC: 5.6 nTPM
neutrophil: 3.9 nTPM
NK-cell: 3.7 nTPM

Brain region

hypothalamus: 125 nTPM
cerebral cortex: 71 nTPM
basal ganglia: 48 nTPM
pons: 40 nTPM
white matter: 40 nTPM
hippocampal formation: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 1.09
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of calcium ion transmembrane transport

Molecular functions

calcium channel regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN13 as an antibody target. Whether an autoantibody or antibody against TSPAN13 could matter depends on whether native TSPAN13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN13 is annotated at the cell surface, where native TSPAN13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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