Seroatlas · Human Serome Atlas

TSPAN11

Tetraspanin-11

Also known as: TSN11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1L157
Gene: TSPAN11
Ensembl: ENSG00000110900
Chromosome: 12
Canonical length: 253 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>A1L157|TSPAN11
     1  MAHYKTEQDD WLIIYLKYLL FVFNFFFWVG GAAVLAVGIW TLVEKSGYLS VLASSTFAAS
    61  AYILIFAGVL VMVTGFLGFG AILWERKGCL STYFCLLLVI FLVELVAGVL AHVYYQRLSD
   121  ELKQHLNRTL AENYGQPGAT QITASVDRLQ QDFKCCGSNS SADWQHSTYI LLREAEGRQV
   181  PDSCCKTVVV RCGQRAHPSN IYKVEGGCLT KLEQFLADHL LLMGAVGIGV ACLQICGMVL
   241  TCCLHQRLQR HFY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

colon: 23 nTPM
cerebellum: 11 nTPM
cerebral cortex: 8.7 nTPM
rectum: 8.3 nTPM
small intestine: 8.3 nTPM
appendix: 7.1 nTPM

Single-cell type

bergmann glia: 124 nCPM
oligodendrocyte progenitor cells: 51 nCPM
respiratory ciliated cells: 35 nCPM
schwann cells: 35 nCPM
tuft cells: 35 nCPM
lymphatic endothelial cells: 32 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 21 nTPM
thalamus: 14 nTPM
midbrain: 13 nTPM
amygdala: 13 nTPM
basal ganglia: 12 nTPM
cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

focal adhesion assembly

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN11 as an antibody target. Whether an autoantibody or antibody against TSPAN11 could matter depends on whether native TSPAN11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN11 is annotated at the cell surface, where native TSPAN11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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