Seroatlas · Human Serome Atlas

TSPAN10

Tetraspanin-10

Also known as: TSN10_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1Z9
Gene: TSPAN10
Canonical length: 355 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for TSPAN10 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>Q9H1Z9|TSPAN10
     1  MEEGERSPLL SQETAGQKPL SVHRPPTSGC LGPVPREDQA EAWGCSCCPP ETKHQALSGT
    61  PKKGPAPSLS PGSSCVKYLI FLSNFPFSLL GLLALAIGLW GLAVKGSLGS DLGGPLPTDP
   121  MLGLALGGLV VSAASLAGCL GALCENTCLL RGFSGGILAF LVLEAVAGAL VVALWGPLQD
   181  SLEHTLRVAI AHYQDDPDLR FLLDQVQLGL RCCGAASYQD WQQNLYFNCS SPGVQACSLP
   241  ASCCIDPRED GASVNDQCGF GVLRLDADAA QRVVYLEGCG PPLRRWLRAN LAASGGYAIA
   301  VVLLQGAELL LAARLLGALA ARSGAAYGPG AHGEDRAGPQ SPSPGAPPAA KPARG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

skin: 1.5 nTPM
lymph node: 0.9 nTPM
choroid plexus: 0.6 nTPM
parathyroid gland: 0.6 nTPM
placenta: 0.5 nTPM
adipose tissue: 0.4 nTPM

Single-cell type

retinal pigment epithelial cells: 379 nCPM
melanocytes: 32 nCPM
hofbauer cells: 20 nCPM
epididymal principal cells: 14 nCPM
medullary thymic epithelial cells: 9.6 nCPM
extravillous trophoblasts: 9.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2.8 nTPM
choroid plexus: 1.5 nTPM
hypothalamus: 0.9 nTPM
pons: 0.6 nTPM
midbrain: 0.5 nTPM
cerebral cortex: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: 0.02

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSPAN10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ADAM10

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN10 as an antibody target. Whether an autoantibody or antibody against TSPAN10 could matter depends on whether native TSPAN10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN10 is annotated at the cell surface, where native TSPAN10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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