Seroatlas · Human Serome Atlas

TSNARE1

t-SNARE domain-containing protein 1

Also known as: FLJ31164, TSNA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NA8
Gene: TSNARE1
Ensembl: ENSG00000171045
Chromosome: 8
Canonical length: 513 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in synaptic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>Q96NA8|TSNARE1
     1  MSYGSIARGG GLGSRGPFGG PSRQGCQPLE CARCWTEYGI RHFPCPSPES KLQNRCVGKD
    61  GEGDLGPAGT PIVPRARKRG PGVAPEGSRM PEPTSSPTIG PRKDSAAGPH GRMAGPSTTR
   121  AKKRKPNFCP QETEVLVSKV SKHHQLLFGT GLLKAEPTRR YRVWSRILQA VNALGYCRRD
   181  VVDLKHKWRD LRAVVRRKLG DLRKAAHGPS PGSGKPQALA LTPVEQVVAK TFSCQALPSE
   241  GFSLEPPRAT QVDPCNLQEL FQEMSANVFR INSSVTSLER SLQSLGTPSD TQELRDSLHT
   301  AQQETNKTIA ASASSVKQMA ELLRSSCPQE RLQQERPQLD RLKTQLSDAI QCYGVVQKKI
   361  AEKSRALLPM AQRGSKQSPQ APFAELADDE KVFNGSDNMW QGQEQALLPD ITEEDLEAIR
   421  LREEAILQME SNLLDVNQII KDLASMVSEQ GEAVDSIEAS LEAASSHAEA ARQLLAGASR
   481  HQLQRHKIKC CFLSAGVTAL LVIIIIIATS VRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSNARE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

pancreas: 29 nTPM
skin: 28 nTPM
ovary: 21 nTPM
cervix: 17 nTPM
thyroid gland: 17 nTPM
cerebral cortex: 16 nTPM

Single-cell type

corticotrophs: 61 nCPM
thyrotrophs: 59 nCPM
proximal tubule cells: 47 nCPM
retinal amacrine cells: 46 nCPM
somatotrophs: 43 nCPM
retinal ganglion cells: 43 nCPM

Immune cell

intermediate monocyte: 2.3 nTPM
non-classical monocyte: 2 nTPM
basophil: 1.6 nTPM
gdT-cell: 0.9 nTPM
MAIT T-cell: 0.6 nTPM
myeloid DC: 0.6 nTPM

Brain region

cerebral cortex: 54 nTPM
white matter: 43 nTPM
medulla oblongata: 39 nTPM
amygdala: 37 nTPM
pons: 33 nTPM
thalamus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: -0.05
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSNARE1 as an antibody target. Whether an autoantibody or antibody against TSNARE1 could matter depends on whether native TSNARE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSNARE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSNARE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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