TSLP

Protein identityUniProt · HPA

UniProt accession

Q969D9

Gene

TSLP

Ensembl

ENSG00000145777

Chromosome

5

Canonical length

159 aa

Protein class

FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Golgi apparatus,Vesicles

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>Q969D9|TSLP
     1  MFPFALLYVL SVSFRKIFIL QLVGLVLTYD FTNCDFEKIK AAYLSTISKD LITYMSGTKS
    61  TEFNNTVSCS NRPHCLTEIQ SLTFNPTAGC ASLAKEMFAM KTKAALAIWC PGYSETQINA
   121  TQAMKKRRKR KVTTNKCLEQ VSQLQGLWRR FNRPLLKQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSLP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

11 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.58

gnomAD pLI

0

gnomAD missense Z

-0.49

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antimicrobial humoral immune response mediated by antimicrobial peptide
• cell surface receptor signaling pathway via JAK-STAT
• cytokine-mediated signaling pathway
• defense response to fungus
• defense response to Gram-negative bacterium
• interleukin-7-mediated signaling pathway
• negative regulation of apoptotic process
• positive regulation of cell population proliferation
• positive regulation of chemokine production
• positive regulation of cytokine-mediated signaling pathway
• positive regulation of granulocyte colony-stimulating factor production
• positive regulation of inflammatory response
• positive regulation of interleukin-10 production
• positive regulation of interleukin-13 production
• positive regulation of interleukin-5 production
• positive regulation of interleukin-6 production
• positive regulation of mast cell activation
• positive regulation of receptor signaling pathway via STAT
• positive regulation of chemokine (C-C motif) ligand 1 production

Molecular functions

• cytokine activity
• interleukin-7 receptor binding

Cellular components

• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Thymic stromal lymphopoietin
• Thymic stromal lymphopoietin superfamily
• Thymic stromal lymphopoietin

KeywordsUniProt

• Cytokine
• Disulfide bond
• Glycoprotein
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of TSLP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IL7R