Seroatlas · Human Serome Atlas

TSHZ2

Teashirt homolog 2

Also known as: C20orf17, OVC10-2, TSH2, TSH2_HUMAN, ZABC2, ZNF218

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRE2
Gene: TSHZ2
Ensembl: ENSG00000182463
Chromosome: 20
Canonical length: 1034 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

1034 residues, UniProt reviewed canonical sequence.

>Q9NRE2|TSHZ2
     1  MPRRKQQAPK RAAGYAQEEQ LKEEEEIKEE EEEEDSGSVA QLQGGNDTGT DEELETGPEQ
    61  KGCFSYQNSP GSHLSNQDAE NESLLSDASD QVSDIKSVCG RDASDKKAHT HVRLPNEAHN
   121  CMDKMTAVYA NILSDSYWSG LGLGFKLSNS ERRNCDTRNG SNKSDFDWHQ DALSKSLQQN
   181  LPSRSVSKPS LFSSVQLYRQ SSKMCGTVFT GASRFRCRQC SAAYDTLVEL TVHMNETGHY
   241  QDDNRKKDKL RPTSYSKPRK RAFQDMDKED AQKVLKCMFC GDSFDSLQDL SVHMIKTKHY
   301  QKVPLKEPVP TISSKMVTPA KKRVFDVNRP CSPDSTTGSF ADSFSSQKNA NLQLSSNNRY
   361  GYQNGASYTW QFEACKSQIL KCMECGSSHD TLQQLTTHMM VTGHFLKVTS SASKKGKQLV
   421  LDPLAVEKMQ SLSEAPNSDS LAPKPSSNSA SDCTASTTEL KKESKKERPE ETSKDEKVVK
   481  SEDYEDPLQK PLDPTIKYQY LREEDLEDGS KGGGDILKSL ENTVTTAINK AQNGAPSWSA
   541  YPSIHAAYQL SEGTKPPLPM GSQVLQIRPN LTNKLRPIAP KWKVMPLVSM PTHLAPYTQV
   601  KKESEDKDEA VKECGKESPH EEASSFSHSE GDSFRKSETP PEAKKTELGP LKEEEKLMKE
   661  GSEKEKPQPL EPTSALSNGC ALANHAPALP CINPLSALQS VLNNHLGKAT EPLRSPSCSS
   721  PSSSTISMFH KSNLNVMDKP VLSPASTRSA SVSRRYLFEN SDQPIDLTKS KSKKAESSQA
   781  QSCMSPPQKH ALSDIADMVK VLPKATTPKP ASSSRVPPMK LEMDVRRFED VSSEVSTLHK
   841  RKGRQSNWNP QHLLILQAQF ASSLFQTSEG KYLLSDLGPQ ERMQISKFTG LSMTTISHWL
   901  ANVKYQLRKT GGTKFLKNMD KGHPIFYCSD CASQFRTPST YISHLESHLG FQMKDMTRLS
   961  VDQQSKVEQE ISRVSSAQRS PETIAAEEDT DSKFKCKLCC RTFVSKHAVK LHLSKTHSKS
  1021  PEHHSQFVTD VDEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSHZ2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 21 nTPM
ovary: 18 nTPM
epididymis: 16 nTPM
adrenal gland: 14 nTPM
salivary gland: 13 nTPM
seminal vesicle: 13 nTPM

Single-cell type

peritubular myoid cells: 2,233 nCPM
adrenal cortex cells: 2,204 nCPM
leydig cells: 1,862 nCPM
fibro-adipogenic progenitors: 1,840 nCPM
respiratory basal cells: 1,765 nCPM
thyrotrophs: 1,604 nCPM

Immune cell

naive CD4 T-cell: 3 nTPM
T-reg: 2.4 nTPM
memory CD4 T-cell: 2.1 nTPM
neutrophil: 0.6 nTPM
total PBMC: 0.5 nTPM
memory B-cell: 0.4 nTPM

Brain region

spinal cord: 29 nTPM
hypothalamus: 27 nTPM
midbrain: 25 nTPM
thalamus: 25 nTPM
white matter: 23 nTPM
medulla oblongata: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.98
gnomAD missense Z: 0.6
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSHZ2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

APBB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSHZ2 as an antibody target. Whether an autoantibody or antibody against TSHZ2 could matter depends on whether native TSHZ2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSHZ2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSHZ2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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