Seroatlas · Human Serome Atlas

TSHZ1

Teashirt homolog 1

Also known as: NY-CO-33, SDCCAG33, TSH1, TSH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZSZ6
Gene: TSHZ1
Ensembl: ENSG00000179981
Chromosome: 18
Canonical length: 1077 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

1077 residues, UniProt reviewed canonical sequence.

>Q6ZSZ6|TSHZ1
     1  MPRRKQQAPR RSAAYVPEEE LKAAEIDEEH VEDDGLSLDI QESEYMCNEE TEIKEAQSYQ
    61  NSPVSSATNQ DAGYGSPFSE SSDQLAHFKG SSSREEKEDP QCPDSVSYPQ DSLAQIKAVY
   121  ANLFSESCWS SLALDLKKSG STTSTNDASQ KESSAPTPTP PTCPVSTTGP TTSTPSTSCS
   181  SSTSHSSTTS TSSSSGYDWH QAALAKTLQQ TSSYGLLPEP SLFSTVQLYR QNNKLYGSVF
   241  TGASKFRCKD CSAAYDTLVE LTVHMNETGH YRDDNRDKDS EKTKRWSKPR KRSLMEMEGK
   301  EDAQKVLKCM YCGHSFESLQ DLSVHMIKTK HYQKVPLKEP VPAITKLVPS TKKRALQDLA
   361  PPCSPEPAGM AAEVALSESA KDQKAANPYV TPNNRYGYQN GASYTWQFEA RKAQILKCME
   421  CGSSHDTLQQ LTAHMMVTGH FLKVTTSASK KGKQLVLDPV VEEKIQSIPL PPTTHTRLPA
   481  SSIKKQPDSP AGSTTSEEKK EPEKEKPPVA GDAEKIKEES EDSLEKFEPS TLYPYLREED
   541  LDDSPKGGLD ILKSLENTVS TAISKAQNGA PSWGGYPSIH AAYQLPGTVK PLPAAVQSVQ
   601  VQPSYAGGVK SLSSAEHNAL LHSPGSLTPP PHKSNVSAME ELVEKVTGKV NIKKEERPPE
   661  KEKSSLAKAA SPIAKENKDF PKTEEVSGKP QKKGPEAETG KAKKEGPLDV HTPNGTEPLK
   721  AKVTNGCNNL GIIMDHSPEP SFINPLSALQ SIMNTHLGKV SKPVSPSLDP LAMLYKISNS
   781  MLDKPVYPAT PVKQADAIDR YYYENSDQPI DLTKSKNKPL VSSVADSVAS PLRESALMDI
   841  SDMVKNLTGR LTPKSSTPST VSEKSDADGS SFEEALDELS PVHKRKGRQS NWNPQHLLIL
   901  QAQFASSLRE TTEGKYIMSD LGPQERVHIS KFTGLSMTTI SHWLANVKYQ LRRTGGTKFL
   961  KNLDTGHPVF FCNDCASQFR TASTYISHLE THLGFSLKDL SKLPLNQIQE QQNVSKVLTN
  1021  KTLGPLGATE EDLGSTFQCK LCNRTFASKH AVKLHLSKTH GKSPEDHLIY VTELEKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSHZ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

ovary: 35 nTPM
placenta: 28 nTPM
cerebellum: 19 nTPM
colon: 17 nTPM
cervix: 16 nTPM
fallopian tube: 15 nTPM

Single-cell type

peritubular myoid cells: 224 nCPM
corticotrophs: 197 nCPM
podocytes: 181 nCPM
thyrotrophs: 164 nCPM
lactotrophs: 138 nCPM
oligodendrocyte progenitor cells: 118 nCPM

Immune cell

naive CD8 T-cell: 2.2 nTPM
gdT-cell: 2.1 nTPM
memory CD8 T-cell: 1.8 nTPM
naive CD4 T-cell: 1.5 nTPM
NK-cell: 1.5 nTPM
MAIT T-cell: 1.4 nTPM

Brain region

cerebellum: 52 nTPM
cerebral cortex: 47 nTPM
spinal cord: 46 nTPM
medulla oblongata: 43 nTPM
pons: 43 nTPM
hippocampal formation: 39 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TSHZ1.

Disease | AllUniProt

Conditions TSHZ1 is implicated in, by any mechanism.

Aural atresia, congenital (CAA) MIM:607842

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 267 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Aural atresia, congenital

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 1.29
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSHZ1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

APBB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSHZ1 as an antibody target. Whether an autoantibody or antibody against TSHZ1 could matter depends on whether native TSHZ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSHZ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries.

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