Seroatlas · Human Serome Atlas

TSGA13

Testis-specific gene 13 protein

Also known as: TSG13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PP4
Gene: TSGA13
Ensembl: ENSG00000213265
Chromosome: 7
Canonical length: 275 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

No narrative summary is available for TSGA13 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q96PP4|TSGA13
     1  MSQKRQTKFQ NGKSKTSENS SAKREKGMVV NSKEISDAVG QSKFVLENLR HYTVHPNLAQ
    61  YYKPLKATAL QKFLAQNRKN TSFMLKVTQY DQDKTLLIMT NNPPPCSITQ QDKESASKYF
   121  SKELLLKVME SHHQHKPTEN LWLPRMPQKK KLRSKLKPIF PLILSDDPTS KREQWFRFST
   181  DNDFKSEGKY SKVYALRTQK KMYPQLTFAP VHERDMRKDA SKKSASERPI SKVIREPLTL
   241  ASLLEDMPTR TAPGESAFRN GRAPQWIIKK ATVIG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSGA13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
fallopian tube: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late spermatids: 385 nCPM
late primary spermatocytes: 75 nCPM
early spermatids: 73 nCPM
cholangiocytes: 2 nCPM
foveolar cells: 1.5 nCPM
adipocytes: 1.2 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 0.5 nTPM
cerebellum: 0.5 nTPM
hypothalamus: 0.5 nTPM
amygdala: 0.4 nTPM
cerebral cortex: 0.4 nTPM
medulla oblongata: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: -0.47
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Testis-specific gene 13 protein
Testis-specific gene 13 protein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSGA13 as an antibody target. Whether an autoantibody or antibody against TSGA13 could matter depends on whether native TSGA13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSGA13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSGA13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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