Seroatlas · Human Serome Atlas

TSGA10IP

Testis-specific protein 10-interacting protein

Also known as: FAM161C, FLJ32880, T10IP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3SY00
Gene: TSGA10IP
Ensembl: ENSG00000175513
Chromosome: 11
Canonical length: 556 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mid piece

OverviewNCBI Gene

Predicted to be involved in cilium organization. Predicted to be located in cytoskeleton. Predicted to be active in photoreceptor connecting cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

556 residues, UniProt reviewed canonical sequence.

>Q3SY00|TSGA10IP
     1  MGQDTDMLNT YQQLVRTPSV RPGQDVRLQA PGTRTGLLKL LSTVSQDKQG CLGSGDGVPN
    61  QDLQQRSQSS RQTAKKDRKP RGQSKKGQGS EESEDHFPLL PRKPSFPFQW AWESIATDVR
   121  AVLQPSSPTP GHQALPMPSS FSQRQSRRKS TANLPEAHGC CWKTEAQNLK ARQQLGAWGG
   181  VSIPTGKGEL GSEPPSGLQL PGRRPGSGSA SDKQVQLQSL GAEEAERGLS SGVLPQRPRR
   241  GSISEEEQFS EATEEAEEGE HRTPCRRRAG CQRKGQISGE EASDEGEVQG QSQGSSPSFN
   301  NLRRRQWRKT RAKELQGPWD LEKLHRQLQR DLDCGPQKLP WKTLRAAFQA SKRNGKAYAS
   361  GYDETFVSAN LPNRTFHKRQ EATRSLLQAW ERQRQEERQQ AELRRARTQH VQRQVAHCLA
   421  AYAPRGSRGP GAAQRKLEEL RRQERQRFAE YQAELQGIQH RVQARPFLFQ QAMQANARLT
   481  VTRRFSQVLS ALGLDEEQLL SEAGKVDREG TPRKPRSHRS MGVRMEHSPQ RPPRTEPTGS
   541  QPDRHYNPSL DPECSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSGA10IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

testis: 9.4 nTPM
cerebellum: 0.7 nTPM
hypothalamus: 0.5 nTPM
thyroid gland: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 89 nCPM
late primary spermatocytes: 48 nCPM
early spermatids: 48 nCPM
melanocytes: 34 nCPM
epicardial cells: 6.8 nCPM
early primary spermatocytes: 3.2 nCPM

Immune cell

myeloid DC: 0.4 nTPM
eosinophil: 0.3 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 0.8 nTPM
cerebellum: 0.7 nTPM
spinal cord: 0.5 nTPM
medulla oblongata: 0.3 nTPM
midbrain: 0.3 nTPM
thalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cilium organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

FAM161

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSGA10IP as an antibody target. Whether an autoantibody or antibody against TSGA10IP could matter depends on whether native TSGA10IP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSGA10IP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSGA10IP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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