TSGA10

Protein identityUniProt · HPA

UniProt accession

Q9BZW7

Gene

TSGA10

Ensembl

ENSG00000135951

Chromosome

2

Canonical length

698 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Flagellar centriole

OverviewNCBI Gene

Predicted to enable structural molecule activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within cell projection assembly. Predicted to be located in neuron projection; sperm fibrous sheath; and sperm principal piece. Predicted to be active in motile cilium. Implicated in spermatogenic failure 26. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

698 residues, UniProt reviewed canonical sequence.

>Q9BZW7|TSGA10
     1  MMRSRSKSPR RPSPTARGAN CDVELLKTTT RDREELKCML EKYERHLAEI QGNVKVLKSE
    61  RDKIFLLYEQ AQEEITRLRR EMMKSCKSPK STTAHAILRR VETERDVAFT DLRRMTTERD
   121  SLRERLKIAQ ETAFNEKAHL EQRIEELECT VHNLDDERME QMSNMTLMKE TISTVEKEMK
   181  SLARKAMDTE SELGRQKAEN NSLRLLYENT EKDLSDTQRH LAKKKYELQL TQEKIMCLDE
   241  KIDNFTRQNI AQREEISILG GTLNDLAKEK ECLQACLDKK SENIASLGES LAMKEKTISG
   301  MKNIIAEMEQ ASRQCTEALI VCEQDVSRMR RQLDETNDEL AQIARERDIL AHDNDNLQEQ
   361  FAKAKQENQA LSKKLNDTHN ELNDIKQKVQ DTNLEVNKLK NILKSEESEN RQMMEQLRKA
   421  NEDAENWENK ARQSEADNNT LKLELITAEA EGNRLKEKVD SLNREVEQHL NAERSYKSQI
   481  STLHKSVVKM EEELQKVQFE KVSALADLSS TRELCIKLDS SKELLNRQLV AKDQEIEMRE
   541  NELDSAHSEI ELLRSQMANE RISMQNLEAL LVANRDKEYQ SQIALQEKES EIQLLKEHLC
   601  LAENKMAIQS RDVAQFRNVV TQLEADLDIT KRQLGTERFE RERAVQELRR QNYSSNAYHM
   661  SSTMKPNTKC HSPERAHHRS PDRGLDRSLE ENLCYRDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSGA10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

48 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TSGA10.

Disease | AllUniProt

Conditions TSGA10 is implicated in, by any mechanism.

• Spermatogenic failure 26 (SPGF26) MIM:617961

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 113 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Spermatogenic failure 26

ReferencesPubMed · IEDB

Publications for TSGA10 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.41

gnomAD pLI

0.11

gnomAD missense Z

0.75

DepMap mean gene effect

-0.25

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell projection assembly
• spermatogenesis

Cellular components

• centriole
• cytoplasm
• motile cilium
• neuron projection
• sperm fibrous sheath
• sperm principal piece

Protein domainsUniProt · Pfam · InterPro

• Centriole and Basal Body Structural Protein

KeywordsUniProt

• Cytoplasm
• Cytoskeleton
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of TSGA10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HIF1A