Seroatlas · Human Serome Atlas

TSEN2

tRNA-splicing endonuclease subunit Sen2

Also known as: MGC2776, SEN2, SEN2_HUMAN, SEN2L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NCE0
Gene
TSEN2
Ensembl
ENSG00000154743
Chromosome
3
Canonical length
465 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q8NCE0|TSEN2
     1  MAEAVFHAPK RKRRVYETYE SPLPIPFGQD HGPLKEFKIF RAEMINNNVI VRNAEDIEQL
    61  YGKGYFGKGI LSRSRPSFTI SDPKLVAKWK DMKTNMPIIT SKRYQHSVEW AAELMRRQGQ
   121  DESTVRRILK DYTKPLEHPP VKRNEEAQVH DKLNSGMVSN MEGTAGGERP SVVNGDSGKS
   181  GGVGDPREPL GCLQEGSGCH PTTESFEKSV REDASPLPHV CCCKQDALIL QRGLHHEDGS
   241  QHIGLLHPGD RGPDHEYVLV EEAECAMSER EAAPNEELVQ RNRLICRRNP YRIFEYLQLS
   301  LEEAFFLVYA LGCLSIYYEK EPLTIVKLWK AFTVVQPTFR TTYMAYHYFR SKGWVPKVGL
   361  KYGTDLLLYR KGPPFYHASY SVIIELVDDH FEGSLRRPLS WKSLAALSRV SVNVSKELML
   421  CYLIKPSTMT DKEMESPECM KRIKVQEVIL SRWVSSRERS DQDDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSEN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
5.2 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 5.2 nTPM
  • skeletal muscle: 4.2 nTPM
  • cerebellum: 4 nTPM
  • spinal cord: 3.9 nTPM
  • basal ganglia: 3.8 nTPM
  • choroid plexus: 3.8 nTPM

Single-cell type

  • adipocytes: 141 nCPM
  • choroid plexus epithelial cells: 95 nCPM
  • myonuclei: 89 nCPM
  • rod photoreceptor cells: 81 nCPM
  • thyrotrophs: 81 nCPM
  • differentiating spermatogonia: 78 nCPM

Immune cell

  • naive CD4 T-cell: 6.2 nTPM
  • naive CD8 T-cell: 5.1 nTPM
  • memory CD4 T-cell: 4.6 nTPM
  • MAIT T-cell: 4.4 nTPM
  • memory CD8 T-cell: 3.8 nTPM
  • memory B-cell: 3.7 nTPM

Brain region

  • cerebellum: 4.3 nTPM
  • basal ganglia: 3.5 nTPM
  • cerebral cortex: 3.5 nTPM
  • hypothalamus: 3.3 nTPM
  • choroid plexus: 3.2 nTPM
  • white matter: 3.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TSEN2.

Disease | AllUniProt

Conditions TSEN2 is implicated in, by any mechanism.

Disease | GeneticClinVar

27 pathogenic / likely-pathogenic of 366 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
-1
DepMap mean gene effect
-0.6
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSEN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSEN2 as an antibody target. Whether an autoantibody or antibody against TSEN2 could matter depends on whether native TSEN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSEN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSEN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TSEN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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