Seroatlas · Human Serome Atlas

TSEN15

tRNA-splicing endonuclease subunit Sen15

Also known as: C1orf19, SEN15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WW01
Gene
TSEN15
Ensembl
ENSG00000198860
Chromosome
1
Canonical length
171 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

171 residues, UniProt reviewed canonical sequence.

>Q8WW01|TSEN15
     1  MEERGDSEPT PGCSGLGPGG VRGFGDGGGA PSWAPEDAWM GTHPKYLEMM ELDIGDATQV
    61  YVAFLVYLDL MESKSWHEVN CVGLPELQLI CLVGTEIEGE GLQTVVPTPI TASLSHNRIR
   121  EILKASRKLQ GDPDLPMSFT LAIVESDSTI VYYKLTDGFM LPDPQNISLR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSEN15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 40 nTPM
  • skeletal muscle: 34 nTPM
  • midbrain: 28 nTPM
  • epididymis: 26 nTPM
  • thymus: 26 nTPM
  • heart muscle: 25 nTPM

Single-cell type

  • oligodendrocytes: 99 nCPM
  • podocytes: 81 nCPM
  • myonuclei: 78 nCPM
  • choroid plexus epithelial cells: 68 nCPM
  • plasma cells: 66 nCPM
  • differentiating spermatogonia: 65 nCPM

Immune cell

  • NK-cell: 55 nTPM
  • T-reg: 40 nTPM
  • myeloid DC: 36 nTPM
  • memory CD8 T-cell: 35 nTPM
  • total PBMC: 35 nTPM
  • gdT-cell: 34 nTPM

Brain region

  • white matter: 61 nTPM
  • cerebral cortex: 51 nTPM
  • medulla oblongata: 50 nTPM
  • basal ganglia: 48 nTPM
  • hypothalamus: 48 nTPM
  • thalamus: 47 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TSEN15.

Disease | AllUniProt

Conditions TSEN15 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 67 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Pontocerebellar hypoplasia, type 2F

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0.28
gnomAD missense Z
1.17
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSEN15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSEN15 as an antibody target. Whether an autoantibody or antibody against TSEN15 could matter depends on whether native TSEN15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSEN15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSEN15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TSEN15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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