Seroatlas · Human Serome Atlas

TRPV2

Transient receptor potential cation channel subfamily V member 2

Also known as: TRPV2_HUMAN, VRL, VRL-1, VRL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5S1
Gene
TRPV2
Ensembl
ENSG00000187688
Chromosome
17
Canonical length
764 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

764 residues, UniProt reviewed canonical sequence.

>Q9Y5S1|TRPV2
     1  MTSPSSSPVF RLETLDGGQE DGSEADRGKL DFGSGLPPME SQFQGEDRKF APQIRVNLNY
    61  RKGTGASQPD PNRFDRDRLF NAVSRGVPED LAGLPEYLSK TSKYLTDSEY TEGSTGKTCL
   121  MKAVLNLKDG VNACILPLLQ IDRDSGNPQP LVNAQCTDDY YRGHSALHIA IEKRSLQCVK
   181  LLVENGANVH ARACGRFFQK GQGTCFYFGE LPLSLAACTK QWDVVSYLLE NPHQPASLQA
   241  TDSQGNTVLH ALVMISDNSA ENIALVTSMY DGLLQAGARL CPTVQLEDIR NLQDLTPLKL
   301  AAKEGKIEIF RHILQREFSG LSHLSRKFTE WCYGPVRVSL YDLASVDSCE ENSVLEIIAF
   361  HCKSPHRHRM VVLEPLNKLL QAKWDLLIPK FFLNFLCNLI YMFIFTAVAY HQPTLKKQAA
   421  PHLKAEVGNS MLLTGHILIL LGGIYLLVGQ LWYFWRRHVF IWISFIDSYF EILFLFQALL
   481  TVVSQVLCFL AIEWYLPLLV SALVLGWLNL LYYTRGFQHT GIYSVMIQKV ILRDLLRFLL
   541  IYLVFLFGFA VALVSLSQEA WRPEAPTGPN ATESVQPMEG QEDEGNGAQY RGILEASLEL
   601  FKFTIGMGEL AFQEQLHFRG MVLLLLLAYV LLTYILLLNM LIALMSETVN SVATDSWSIW
   661  KLQKAISVLE MENGYWWCRK KQRAGVMLTV GTKPDGSPDE RWCFRVEEVN WASWEQTLPT
   721  LCEDPSGAGV PRTLENPVLA SPPKEDEDGA SEENYVPVQL LQSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRPV2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • lung: 30 nTPM
  • spleen: 23 nTPM
  • lymph node: 23 nTPM
  • bone marrow: 22 nTPM
  • adrenal gland: 20 nTPM
  • placenta: 19 nTPM

Single-cell type

  • melanocytes: 54 nCPM
  • hepatic stellate cells: 52 nCPM
  • pericytes: 40 nCPM
  • hofbauer cells: 40 nCPM
  • mast cells: 39 nCPM
  • nk-cells: 38 nCPM

Immune cell

  • gdT-cell: 64 nTPM
  • NK-cell: 64 nTPM
  • basophil: 61 nTPM
  • memory CD8 T-cell: 59 nTPM
  • myeloid DC: 59 nTPM
  • MAIT T-cell: 56 nTPM

Brain region

  • pons: 34 nTPM
  • midbrain: 29 nTPM
  • medulla oblongata: 19 nTPM
  • hypothalamus: 18 nTPM
  • white matter: 14 nTPM
  • cerebral cortex: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
1.71
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRPV2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRPV2 as an antibody target. Whether an autoantibody or antibody against TRPV2 could matter depends on whether native TRPV2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRPV2 is annotated at the cell surface, where native TRPV2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRPV2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRPV2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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