Seroatlas · Human Serome Atlas

TRPT1

tRNA 2'-phosphotransferase 1

Also known as: MGC11134, TRPT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86TN4
Gene: TRPT1
Ensembl: ENSG00000149743
Chromosome: 11
Canonical length: 253 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable tRNA 2'-phosphotransferase activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to act upstream of or within regulation of protein kinase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q86TN4|TRPT1
     1  MNFSGGGRQE AAGSRGRRAP RPREQDRDVQ LSKALSYALR HGALKLGLPM GADGFVPLGT
    61  LLQLPQFRGF SAEDVQRVVD TNRKQRFALQ LGDPSTGLLI RANQGHSLQV PKLELMPLET
   121  PQALPPMLVH GTFWKHWPSI LLKGLSCQGR THIHLAPGLP GDPGIISGMR SHCEIAVFID
   181  GPLALADGIP FFRSANGVIL TPGNTDGFLL PKYFKEALQL RPTRKPLSLA GDEETECQSS
   241  PKHSSRERRR IQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRPT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 166 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 166 nTPM
tongue: 108 nTPM
heart muscle: 84 nTPM
kidney: 54 nTPM
pancreas: 49 nTPM
testis: 48 nTPM

Single-cell type

late primary spermatocytes: 182 nCPM
early spermatids: 138 nCPM
esophageal apical cells: 128 nCPM
late spermatids: 101 nCPM
goblet cells: 96 nCPM
esophageal suprabasal cells: 87 nCPM

Immune cell

plasmacytoid DC: 59 nTPM
naive B-cell: 40 nTPM
memory B-cell: 38 nTPM
intermediate monocyte: 31 nTPM
eosinophil: 29 nTPM
non-classical monocyte: 28 nTPM

Brain region

thalamus: 27 nTPM
cerebellum: 26 nTPM
medulla oblongata: 24 nTPM
basal ganglia: 23 nTPM
hypothalamus: 23 nTPM
spinal cord: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via endonucleolytic cleavage and ligation
tRNA splicing

Molecular functions

tRNA 2'-phosphotransferase activity

Protein domainsUniProt · Pfam · InterPro

Phosphotransferase KptA/Tpt1
RNA 2'-phosphotransferase, N-terminal domain
RNA 2'-phosphotransferase, C-terminal domain
RNA 2'-phosphotransferase, Tpt1 / KptA family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRPT1 as an antibody target. Whether an autoantibody or antibody against TRPT1 could matter depends on whether native TRPT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRPT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRPT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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