TRPC5OS
Putative uncharacterized protein TRPC5OS
Also known as: TR5OS_HUMAN, TRPC5-AS1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NMA1
- Gene
- TRPC5OS
- Ensembl
- ENSG00000204025
- Chromosome
- X
- Canonical length
- 111 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for TRPC5OS in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
111 residues, UniProt reviewed canonical sequence.
>A6NMA1|TRPC5OS
1 MDSVLIHVLI DGLVACVAQL IRIADELLQF ILQVQEVPYV EENGRAEETE ADAPLPEEPS
61 LPDLPDLSDL DSILTPREDE DLIFDIDQAM LDMDNLYEDT VSGINDDLTG DLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRPC5OS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- testis: 20 nTPM
- epididymis: 0.6 nTPM
- fallopian tube: 0.2 nTPM
- kidney: 0.2 nTPM
- midbrain: 0.2 nTPM
- amygdala: 0.1 nTPM
Single-cell type
- sertoli cells: 127 nCPM
- oocytes: 4.6 nCPM
- late spermatids: 3.6 nCPM
- undifferentiated spermatogonia: 3.6 nCPM
- other brain neurons: 3.1 nCPM
- brain inhibitory neurons: 2.8 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 2 nTPM
- white matter: 1.8 nTPM
- hypothalamus: 1.6 nTPM
- medulla oblongata: 1.6 nTPM
- hippocampal formation: 1.4 nTPM
- midbrain: 1.3 nTPM
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRPC5OS as an antibody target. Whether an autoantibody or antibody against TRPC5OS could matter depends on whether native TRPC5OS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRPC5OS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TRPC5OS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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