Seroatlas · Human Serome Atlas

TRMT9B

Probable tRNA methyltransferase 9B

Also known as: C8orf79, FLJ36980, hTRM9L, KIAA1456, TRM9B_HUMAN, TRM9L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P272
Gene: TRMT9B
Ensembl: ENSG00000250305
Chromosome: 8
Canonical length: 454 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>Q9P272|TRMT9B
     1  MDHEAAQLEK QHVHNVYEST APYFSDLQSK AWPRVRQFLQ EQKPGSLIAD IGCGTGKYLK
    61  VNSQVHTVGC DYCGPLVEIA RNRGCEAMVC DNLNLPFRDE GFDAIISIGV IHHFSTKQRR
   121  IRAIKEMARV LVPGGQLMIY VWAMEQKNRH FEKQDVLVPW NRALCSQLFS ESSQSGRKRQ
   181  CGYPERGHPY HPPCSECSCS VCFKEQCGSK RSHSVGYEPA MARTCFANIS KEGEEEYGFY
   241  STLGKSFRSW FFSRSLDEST LRKQIERVRP LKNTEVWASS TVTVQPSRHS SLDFDHQEPF
   301  STKGQSLDEE VFVESSSGKH LEWLRAPGTL KHLNGDHQGE MRRNGGGNFL DSTNTGVNCV
   361  DAGNIEDDNP SASKILRRIS AVDSTDFNPD DTMSVEDPQT DVLDSTAFMR YYHVFREGEL
   421  CSLLKENVSE LRILSSGNDH GNWCIIAEKK RGCD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT9B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 82 nTPM
cerebellum: 64 nTPM
thyroid gland: 32 nTPM
retina: 23 nTPM
heart muscle: 5.9 nTPM
cerebral cortex: 4.8 nTPM

Single-cell type

choroid plexus epithelial cells: 3,989 nCPM
ependymal cells: 397 nCPM
bergmann glia: 360 nCPM
brain excitatory neurons: 294 nCPM
distal convoluted tubule cells: 145 nCPM
loop of henle epithelial cells: 139 nCPM

Immune cell

NK-cell: 0.4 nTPM
basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

choroid plexus: 812 nTPM
cerebellum: 262 nTPM
hippocampal formation: 71 nTPM
thalamus: 54 nTPM
pons: 40 nTPM
cerebral cortex: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT9B as an antibody target. Whether an autoantibody or antibody against TRMT9B could matter depends on whether native TRMT9B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT9B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT9B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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