Seroatlas · Human Serome Atlas

TRMT44

Probable tRNA (uracil-O(2)-)-methyltransferase

Also known as: C4orf23, FLJ35725, METTL19, TRM44, TRM44_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYL2
Gene: TRMT44
Ensembl: ENSG00000155275
Chromosome: 4
Canonical length: 757 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nuclear bodies,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a putative tRNA methyltransferase found in the cytoplasm. Defects in this gene may be a cause of partial epilepsy with pericentral spikes (PEPS), but that has not been proven definitively. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

757 residues, UniProt reviewed canonical sequence.

>Q8IYL2|TRMT44
     1  MAEVGRTGIS YPGALLPQGF WAAVEVWLER PQVANKRLCG ARLEARWSAA LPCAEARGPG
    61  TSAGSEQKER GPGPGQGSPG GGPGPRSLSG PEQGTACCEL EEAQGQCQQE EAQREAASVP
   121  LRDSGHPGHA EGREGDFPAA DLDSLWEDFS QSLARGNSEL LAFLTSSGAG SQPEAQRELD
   181  VVLRTVIPKT SPHCPLTTPR REIVVQDVLN GTITFLPLEE DDEGNLKVKM SNVYQIQLSH
   241  SKEEWFISVL IFCPERWHSD GIVYPKPTWL GEELLAKLAK WSVENKKSDF KSTLSLISIM
   301  KYSKAYQELK EKYKEMVKVW PEVTDPEKFV YEDVAIAAYL LILWEEERAE RRLTARQSFV
   361  DLGCGNGLLV HILSSEGHPG RGIDVRRRKI WDMYGPQTQL EEDAITPNDK TLFPDVDWLI
   421  GNHSDELTPW IPVIAARSSY NCRFFVLPCC FFDFIGRYSR RQSKKTQYRE YLDFIKEVGF
   481  TCGFHVDEDC LRIPSTKRVC LVGKSRTYPS SREASVDEKR TQYIKSRRGC PVSPPGWELS
   541  PSPRWVAAGS AGHCDGQQAL DARVGCVTRA WAAEHGAGPQ AEGPWLPGFH PREKAERVRN
   601  CAALPRDFID QVVLQVANLL LGGKQLNTRS SRNGSLKTWN GGESLSLAEV ANELDTETLR
   661  RLKRECGGLQ TLLRNSHQVF QVVNGRVHIR DWREETLWKT KQPEAKQRLL SEACKTRLCW
   721  FFMHHPDGCA LSTDCCPFAH GPAELRPPRT TPRKKIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

skin: 9.1 nTPM
cerebellum: 7.9 nTPM
ovary: 7.5 nTPM
breast: 6.8 nTPM
bone marrow: 6.7 nTPM
esophagus: 6.5 nTPM

Single-cell type

oocytes: 193 nCPM
esophageal apical cells: 161 nCPM
endometrial luminal cells: 71 nCPM
cone photoreceptor cells: 70 nCPM
endometrial glandular cells: 64 nCPM
endometrial ciliated cells: 49 nCPM

Immune cell

naive CD4 T-cell: 0.7 nTPM
gdT-cell: 0.6 nTPM
memory CD8 T-cell: 0.6 nTPM
non-classical monocyte: 0.6 nTPM
memory CD4 T-cell: 0.5 nTPM
myeloid DC: 0.5 nTPM

Brain region

cerebral cortex: 13 nTPM
cerebellum: 13 nTPM
white matter: 13 nTPM
hippocampal formation: 12 nTPM
basal ganglia: 12 nTPM
amygdala: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: -0.85
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

tRNA methylation

Molecular functions

tRNA (uridine) methyltransferase activity
zinc ion binding
tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Zinc finger, CCCH-type
S-adenosyl-L-methionine-dependent methyltransferase superfamily
tRNA (uracil-O(2)-)-methyltransferase
Predicted AdoMet-dependent methyltransferase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT44 as an antibody target. Whether an autoantibody or antibody against TRMT44 could matter depends on whether native TRMT44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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