Seroatlas · Human Serome Atlas

TRMT13

tRNA:m(4)X modification enzyme TRM13 homolog

Also known as: CCDC76, FLJ10287, FLJ11219, TRM13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUP7
Gene: TRMT13
Ensembl: ENSG00000122435
Chromosome: 1
Canonical length: 481 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>Q9NUP7|TRMT13
     1  MATSATSPHA PGFPAEGRCG YYVEKKKRFC RMVVAAGKRF CGEHAGAAEE EDARKRILCP
    61  LDPKHTVYED QLAKHLKKCN SREKPKPDFY IQDINAGLRD ETEIPEQLVP ISSLSEEQLE
   121  KLIKKLRKAS EGLNSTLKDH IMSHPALHDA LNDPKNGDSA TKHLKQQASI LGNIENLKLL
   181  GPRRCFVEFG AGKGKLSHWV DIALKDAEKV HFILVEKVTT RFKVDGKHRK KNSVFERLQI
   241  DIQHLCLNKI PVLREEKLPV VGIGKHLCGM ATDLALRCLV ETYAASFEER NEEPLAKRIK
   301  NDKTEKEIYT LAKEGNEKNV PEKWNPVAGI VIALCCHHRC DWRHYVGKEY FRALGLGAVE
   361  FHYFQRMSSW ATCGMRKTSL ETSNSTTKRQ DNQNDDSEEH DDGGYRITDD GADCLPGLLS
   421  VEEKKKIGHL CKLLIDQGRI QYLQQKGFSP ALQYYTDPLV SLENVLLTAL PNHSSSPETT
   481  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

retina: 20 nTPM
lymph node: 17 nTPM
skin: 14 nTPM
tonsil: 14 nTPM
breast: 14 nTPM
spleen: 13 nTPM

Single-cell type

cardiomyocytes: 134 nCPM
oligodendrocytes: 97 nCPM
myonuclei: 87 nCPM
oocytes: 69 nCPM
distal convoluted tubule cells: 67 nCPM
adrenal medulla cells: 64 nCPM

Immune cell

memory B-cell: 20 nTPM
naive B-cell: 19 nTPM
naive CD4 T-cell: 17 nTPM
naive CD8 T-cell: 14 nTPM
MAIT T-cell: 13 nTPM
plasmacytoid DC: 13 nTPM

Brain region

white matter: 29 nTPM
cerebellum: 19 nTPM
basal ganglia: 19 nTPM
hypothalamus: 19 nTPM
midbrain: 18 nTPM
medulla oblongata: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

tRNA methylation

Molecular functions

Protein domainsUniProt · Pfam · InterPro

TRM13/UPF0224 family, U11-48K-like CHHC zinc finger domain
U11-48K-like CHHC zinc finger
Methyltransferase TRM13
Zinc finger, CCCH-type, TRM13
tRNA:m(4)X modification enzyme Trm13
Methyltransferase TRM13
CCCH zinc finger in TRM13 protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT13 as an antibody target. Whether an autoantibody or antibody against TRMT13 could matter depends on whether native TRMT13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...