Seroatlas · Human Serome Atlas

TRMT11

tRNA (guanine(10)-N(2))-methyltransferase TRMT11

Also known as: C6orf75, dJ187J11.2, MDS024, TRM11, TRM11_HUMAN, TRMT11-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z4G4
Gene
TRMT11
Ensembl
ENSG00000066651
Chromosome
6
Canonical length
463 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nuclear bodies

OverviewNCBI Gene

Enables tRNA (guanine(10)-N2)-methyltransferase activity. Predicted to be involved in methylation and tRNA processing. Located in mitochondrion. Part of tRNA (m2G10) methyltransferase complex. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

463 residues, UniProt reviewed canonical sequence.

>Q7Z4G4|TRMT11
     1  MALSCTLNRY LLLMAQEHLE FRLPEIKSLL LLFGGQFASS QETYGKSPFW ILSIPSEDIA
    61  RNLMKRTVCA KSIFELWGHG QSPEELYSSL KNYPVEKMVP FLHSDSTYKI KIHTFNKTLT
   121  QEEKIKRIDA LEFLPFEGKV NLKKPQHVFS VLEDYGLDPN CIPENPHNIY FGRWIADGQR
   181  ELIESYSVKK RHFIGNTSMD AGLSFIMANH GKVKENDIVF DPFVGTGGLL IACAHFGAYV
   241  YGTDIDYNTV HGLGKATRKN QKWRGPDENI RANLRQYGLE KYYLDVLVSD ASKPSWRKGT
   301  YFDAIITDPP YGIRESTRRT GSQKEIPKGI EKWEKCPESH VPVSLSYHLS DMFLDLLNFA
   361  AETLVLGGRL VYWLPVYTPE YTEEMVPWHP CLELVSNCEQ KLSSHTSRRL ITMEKVKKFE
   421  NRDQYSHLLS DHFLPYQGHN SFREKYFSGV TKRIAKEEKS TQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • liver: 26 nTPM
  • cerebellum: 19 nTPM
  • pituitary gland: 18 nTPM
  • retina: 16 nTPM
  • endometrium: 14 nTPM
  • blood vessel: 14 nTPM

Single-cell type

  • myonuclei: 357 nCPM
  • choroid plexus epithelial cells: 354 nCPM
  • thyrotrophs: 340 nCPM
  • somatotrophs: 329 nCPM
  • brain excitatory neurons: 301 nCPM
  • brain inhibitory neurons: 299 nCPM

Immune cell

  • MAIT T-cell: 11 nTPM
  • naive CD4 T-cell: 9.5 nTPM
  • naive CD8 T-cell: 8.6 nTPM
  • memory CD4 T-cell: 7.9 nTPM
  • NK-cell: 7.7 nTPM
  • memory B-cell: 7.1 nTPM

Brain region

  • cerebellum: 28 nTPM
  • cerebral cortex: 21 nTPM
  • white matter: 19 nTPM
  • hypothalamus: 17 nTPM
  • midbrain: 16 nTPM
  • basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT11 as an antibody target. Whether an autoantibody or antibody against TRMT11 could matter depends on whether native TRMT11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRMT11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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