TRMT10B
tRNA methyltransferase 10 homolog B
Also known as: bA3J10.9, FLJ31455, RG9MTD3, TM10B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6PF06
- Gene
- TRMT10B
- Ensembl
- ENSG00000165275
- Chromosome
- 9
- Canonical length
- 316 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Plasma membrane
OverviewNCBI Gene
Enables tRNA (guanosine(9)-N1)-methyltransferase activity. Involved in protein insertion into mitochondrial inner membrane. Located in cytosol and mitochondrial inner membrane. Part of TIM22 mitochondrial import inner membrane insertion complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
316 residues, UniProt reviewed canonical sequence.
>Q6PF06|TRMT10B
1 MDWKLEGSTQ KVESPVLQGQ EGILEETGED GLPEGFQLLQ IDAEGECQEG EILATGSTAW
61 CSKNVQRKQR HWEKIVAAKK SKRKQEKERR KANRAENPGI CPQHSKRFLR ALTKDKLLEA
121 KHSGPRLCID LSMTHYMSKK ELSRLAGQIR RLYGSNKKAD RPFWICLTGF TTDSPLYEEC
181 VRMNDGFSSY LLDITEEDCF SLFPLETLVY LTPDSEHALE DVDLNKVYIL GGLVDESIQK
241 KVTFQKAREY SVKTARLPIQ EYMVRNQNGK NYHSEILAIN QVFDILSTYL ETHNWPEALK
301 KGVSSGKGYI LRNSVELocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRMT10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 10 nTPM
Expression across tissuesHPA
Tissue
- skin: 10 nTPM
- ovary: 9.2 nTPM
- cerebellum: 8.3 nTPM
- colon: 8 nTPM
- prostate: 8 nTPM
- cervix: 7.8 nTPM
Single-cell type
- bergmann glia: 80 nCPM
- leydig cells: 76 nCPM
- fibro-adipogenic progenitors: 71 nCPM
- tuft cells: 69 nCPM
- peritubular myoid cells: 66 nCPM
- oligodendrocytes: 66 nCPM
Immune cell
- naive B-cell: 4.2 nTPM
- MAIT T-cell: 3.8 nTPM
- basophil: 3.4 nTPM
- memory B-cell: 3.4 nTPM
- naive CD4 T-cell: 3.2 nTPM
- gdT-cell: 3.1 nTPM
Brain region
- cerebellum: 24 nTPM
- white matter: 22 nTPM
- medulla oblongata: 19 nTPM
- basal ganglia: 19 nTPM
- cerebral cortex: 18 nTPM
- midbrain: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.02
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.3
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- tRNA (guanine(9)-N1)-methyltransferase, eukaryotic
- tRNA methyltransferase TRM10-type domain
- tRNA methyltransferase TRM10-type domain superfamily
- tRNA methyltransferase 10 homolog B, TRM10-type domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRMT10B as an antibody target. Whether an autoantibody or antibody against TRMT10B could matter depends on whether native TRMT10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRMT10B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TRMT10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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