Seroatlas · Human Serome Atlas

TRMT10A

tRNA methyltransferase 10 homolog A

Also known as: MGC27034, RG9MTD2, TM10A_HUMAN, TRM10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TBZ6
Gene
TRMT10A
Ensembl
ENSG00000145331
Chromosome
4
Canonical length
339 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Actin filaments,Cytosol

OverviewNCBI Gene

This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>Q8TBZ6|TRMT10A
     1  MSSEMLPAFI ETSNVDKKQG INEDQEESQK PRLGEGCEPI SKRQMKKLIK QKQWEEQREL
    61  RKQKRKEKRK RKKLERQCQM EPNSDGHDRK RVRRDVVHST LRLIIDCSFD HLMVLKDIKK
   121  LHKQIQRCYA ENRRALHPVQ FYLTSHGGQL KKNMDENDKG WVNWKDIHIK PEHYSELIKK
   181  EDLIYLTSDS PNILKELDES KAYVIGGLVD HNHHKGLTYK QASDYGINHA QLPLGNFVKM
   241  NSRKVLAVNH VFEIILEYLE TRDWQEAFFT ILPQRKGAVP TDKACESASH DNQSVRMEEG
   301  GSDSDSSEEE YSRNELDSPH EEKQDKENHT ESTVNSLPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT10A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
9.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 9.3 nTPM
  • liver: 9.2 nTPM
  • thyroid gland: 5.7 nTPM
  • fallopian tube: 5.5 nTPM
  • pancreas: 5.5 nTPM
  • kidney: 4.6 nTPM

Single-cell type

  • early primary spermatocytes: 114 nCPM
  • late primary spermatocytes: 66 nCPM
  • differentiating spermatogonia: 58 nCPM
  • undifferentiated spermatogonia: 58 nCPM
  • megakaryocytes: 50 nCPM
  • hepatocytes: 39 nCPM

Immune cell

  • naive B-cell: 5.8 nTPM
  • myeloid DC: 5.2 nTPM
  • neutrophil: 4.9 nTPM
  • classical monocyte: 3.9 nTPM
  • T-reg: 3.9 nTPM
  • intermediate monocyte: 3.8 nTPM

Brain region

  • white matter: 8.2 nTPM
  • pons: 5.6 nTPM
  • medulla oblongata: 5.5 nTPM
  • spinal cord: 5 nTPM
  • cerebellum: 4.9 nTPM
  • basal ganglia: 4.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRMT10A.

Disease | AllUniProt

Conditions TRMT10A is implicated in, by any mechanism.

  • Microcephaly, short stature, and impaired glucose metabolism 1 (MSSGM1) MIM:616033

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 167 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT10A as an antibody target. Whether an autoantibody or antibody against TRMT10A could matter depends on whether native TRMT10A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT10A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT10A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRMT10A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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