Seroatlas · Human Serome Atlas

TRIQK

Triple QxxK/R motif-containing protein

Also known as: C8orf83, DKFZp779L1068, LOC286144, PRO0845, TRIQK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q629K1
Gene
TRIQK
Ensembl
ENSG00000205133
Chromosome
8
Canonical length
86 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

86 residues, UniProt reviewed canonical sequence.

>Q629K1|TRIQK
     1  MGRKDAATIK LPVDQYRKQI GKQDYKKTKP ILRATKLKAE AKKTAIGIKE VGLVLAAILA
    61  LLLAFYAFFY LRLTTDVDPD LDQDED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIQK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • liver: 29 nTPM
  • thyroid gland: 22 nTPM
  • gallbladder: 22 nTPM
  • adrenal gland: 21 nTPM
  • rectum: 20 nTPM
  • colon: 19 nTPM

Single-cell type

  • cardiomyocytes: 178 nCPM
  • neutrophil progenitors: 165 nCPM
  • neutrophils: 126 nCPM
  • prostatic glandular cells: 103 nCPM
  • retinal ganglion cells: 85 nCPM
  • respiratory ciliated cells: 82 nCPM

Immune cell

  • non-classical monocyte: 33 nTPM
  • intermediate monocyte: 19 nTPM
  • classical monocyte: 17 nTPM
  • eosinophil: 16 nTPM
  • neutrophil: 15 nTPM
  • myeloid DC: 9.4 nTPM

Brain region

  • cerebellum: 39 nTPM
  • white matter: 35 nTPM
  • basal ganglia: 33 nTPM
  • spinal cord: 30 nTPM
  • medulla oblongata: 29 nTPM
  • hypothalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.76
gnomAD pLI
0.01
gnomAD missense Z
0.19
DepMap mean gene effect
0.15
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Triple repetitive-sequence of QXXK/R protein
  • Triple QxxK/R motif-containing protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIQK as an antibody target. Whether an autoantibody or antibody against TRIQK could matter depends on whether native TRIQK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIQK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIQK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIQK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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