Seroatlas · Human Serome Atlas

TRIL

TLR4 interactor with leucine rich repeats

Also known as: KIAA0644, TRIL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L0X0
Gene: TRIL
Ensembl: ENSG00000255690
Chromosome: 7
Canonical length: 811 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr 2010]

Canonical amino-acid sequenceUniProt

811 residues, UniProt reviewed canonical sequence.

>Q7L0X0|TRIL
     1  MEAARALRLL LVVCGCLALP PLAEPVCPER CDCQHPQHLL CTNRGLRVVP KTSSLPSPHD
    61  VLTYSLGGNF ITNITAFDFH RLGQLRRLDL QYNQIRSLHP KTFEKLSRLE ELYLGNNLLQ
   121  ALAPGTLAPL RKLRILYANG NEISRLSRGS FEGLESLVKL RLDGNALGAL PDAVFAPLGN
   181  LLYLHLESNR IRFLGKNAFA QLGKLRFLNL SANELQPSLR HAATFAPLRS LSSLILSANN
   241  LQHLGPRIFQ HLPRLGLLSL RGNQLTHLAP EAFWGLEALR ELRLEGNRLS QLPTALLEPL
   301  HSLEALDLSG NELSALHPAT FGHLGRLREL SLRNNALSAL SGDIFAASPA LYRLDLDGNG
   361  WTCDCRLRGL KRWMGDWHSQ GRLLTVFVQC RHPPALRGKY LDYLDDQQLQ NGSCADPSPS
   421  ASLTADRRRQ PLPTAAGEEM TPPAGLAEEL PPQPQLQQQG RFLAGVAWDG AARELVGNRS
   481  ALRLSRRGPG LQQPSPSVAA AAGPAPQSLD LHKKPQRGRP TRADPALAEP TPTASPGSAP
   541  SPAGDPWQRA TKHRLGTEHQ ERAAQSDGGA GLPPLVSDPC DFNKFILCNL TVEAVGADSA
   601  SVRWAVREHR SPRPLGGARF RLLFDRFGQQ PKFHRFVYLP ESSDSATLRE LRGDTPYLVC
   661  VEGVLGGRVC PVAPRDHCAG LVTLPEAGSR GGVDYQLLTL ALLTVNALLV LLALAAWASR
   721  WLRRKLRARR KGGAPVHVRH MYSTRRPLRS MGTGVSADFS GFQSHRPRTT VCALSEADLI
   781  EFPCDRFMDS AGGGAGGSLR REDRLLQRFA D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

midbrain: 38 nTPM
basal ganglia: 35 nTPM
amygdala: 33 nTPM
cerebral cortex: 27 nTPM
hippocampal formation: 21 nTPM
hypothalamus: 19 nTPM

Single-cell type

astrocytes: 70 nCPM
ependymal cells: 63 nCPM
bergmann glia: 62 nCPM
breast myoepithelial cells: 22 nCPM
müller glia: 18 nCPM
oligodendrocyte progenitor cells: 18 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 142 nTPM
midbrain: 132 nTPM
basal ganglia: 124 nTPM
medulla oblongata: 118 nTPM
cerebellum: 117 nTPM
spinal cord: 102 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LPS
TLR4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIL as an antibody target. Whether an autoantibody or antibody against TRIL could matter depends on whether native TRIL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIL is annotated at the cell surface, where native TRIL is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRIL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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