TRHR

Protein identityUniProt · HPA

UniProt accession

P34981

Gene

TRHR

Ensembl

ENSG00000174417

Chromosome

8

Canonical length

398 aa

Protein class

Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>P34981|TRHR
     1  MENETVSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV MRTKHMRTPT
    61  NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC ITYLQYLGIN ASSCSITAFT
   121  IERYIAICHP IKAQFLCTFS RAKKIIIFVW AFTSLYCMLW FFLLDLNIST YKDAIVISCG
   181  YKISRNYYSP IYLMDFGVFY VVPMILATVL YGFIARILFL NPIPSDPKEN SKTWKNDSTH
   241  QNTNLNVNTS NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW
   301  FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKPANYSV ALNYSVIKES
   361  DHFSTELDDI TVTDTYLSAT KVSFDDTCLA SEVSFSQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRHR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

0.6 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRHR.

Disease | AllUniProt

Conditions TRHR is implicated in, by any mechanism.

• Hypothyroidism, congenital, non-goitrous, 7 (CHNG7) MIM:618573

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 65 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hypothyroidism, congenital, nongoitrous, 7

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.64

gnomAD pLI

0.27

gnomAD missense Z

0.94

DepMap mean gene effect

0.18

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled receptor signaling pathway
• phospholipase C-activating G protein-coupled receptor signaling pathway

Molecular functions

• thyrotropin-releasing hormone receptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• GPCR, rhodopsin-like, 7TM
• 7 transmembrane receptor (rhodopsin family)
• Thyrotropin-releasing hormone receptor

KeywordsUniProt

• Cell membrane
• Congenital hypothyroidism
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix