TRHDE

Protein identityUniProt · HPA

UniProt accession

Q9UKU6

Gene

TRHDE

Ensembl

ENSG00000072657

Chromosome

12

Canonical length

1069 aa

Protein class

Enzymes, Metabolic proteins, Predicted membrane proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.[provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

1069 residues, UniProt reviewed canonical sequence.

>Q9UKU6|TRHDE
     1  MALDGELGEQ EEEKKKKKKK KRKKKKEEEE EEEGAEKSSS PFAAAMGEDD AALRAGSRGL
    61  SDPWADSVGV RPRTTERHIA VHKRLVLAFA VSLVALLAVT MLAVLLSLRF DECGASATPG
   121  ADGGPSGFPE RGGNGSLPGS ARRNHHAGGD SWQPEAGGVA SPGTTSAQPP SEEEREPWEP
   181  WTQLRLSGHL KPLHYNLMLT AFMENFTFSG EVNVEIACRN ATRYVVLHAS RVAVEKVQLA
   241  EDRAFGAVPV AGFFLYPQTQ VLVVVLNRTL DAQRNYNLKI IYNALIENEL LGFFRSSYVL
   301  HGERRFLGVT QFSPTHARKA FPCFDEPIYK ATFKISIKHQ ATYLSLSNMP VETSVFEEDG
   361  WVTDHFSQTP LMSTYYLAWA ICNFTYRETT TKSGVVVRLY ARPDAIRRGS GDYALHITKR
   421  LIEFYEDYFK VPYSLPKLDL LAVPKHPYAA MENWGLSIFV EQRILLDPSV SSISYLLDVT
   481  MVIVHEICHQ WFGDLVTPVW WEDVWLKEGF AHYFEFVGTD YLYPGWNMEK QRFLTDVLHE
   541  VMLLDGLASS HPVSQEVLQA TDIDRVFDWI AYKKGAALIR MLANFMGHSV FQRGLQDYLT
   601  IHKYGNAARN DLWNTLSEAL KRNGKYVNIQ EVMDQWTLQM GYPVITILGN TTAENRIIIT
   661  QQHFIYDISA KTKALKLQNN SYLWQIPLTI VVGNRSHVSS EAIIWVSNKS EHHRITYLDK
   721  GSWLLGNINQ TGYFRVNYDL RNWRLLIDQL IRNHEVLSVS NRAGLIDDAF SLARAGYLPQ
   781  NIPLEIIRYL SEEKDFLPWH AASRALYPLD KLLDRMENYN IFNEYILKQV ATTYIKLGWP
   841  KNNFNGSLVQ ASYQHEELRR EVIMLACSFG NKHCHQQAST LISDWISSNR NRIPLNVRDI
   901  VYCTGVSLLD EDVWEFIWMK FHSTTAVSEK KILLEALTCS DDRNLLNRLL NLSLNSEVVL
   961  DQDAIDVIIH VARNPHGRDL AWKFFRDKWK ILNTRYGEAL FMNSKLISGV TEFLNTEGEL
  1021  KELKNFMKNY DGVAAASFSR AVETVEANVR WKMLYQDELF QWLGKALRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRHDE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

11 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.55

gnomAD pLI

0

gnomAD missense Z

2.79

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-cell signaling
• peptide catabolic process
• proteolysis
• signal transduction

Molecular functions

• aminopeptidase activity
• metalloaminopeptidase activity
• pyroglutamyl-peptidase activity
• zinc ion binding

Cellular components

• extracellular exosome
• extracellular space
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
• Peptidase M1, membrane alanine aminopeptidase
• ERAP1-like C-terminal domain
• Peptidase M4/M1, CTD superfamily
• Aminopeptidase N-type
• Aminopeptidase N-like , N-terminal domain superfamliy
• Aminopeptidase N-like , N-terminal domain
• Peptidase M1 family aminopeptidases
• Peptidase family M1 domain
• ERAP1-like C-terminal domain
• Peptidase M1 N-terminal domain

KeywordsUniProt

• Aminopeptidase
• Disulfide bond
• Glycoprotein
• Hydrolase
• Membrane
• Metal-binding
• Metalloprotease
• Protease
• Signal-anchor
• Transmembrane
• Transmembrane helix
• Zinc