Seroatlas · Human Serome Atlas

TRH

Pro-thyrotropin-releasing hormone

Also known as: TRH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P20396
Gene: TRH
Ensembl: ENSG00000170893
Chromosome: 3
Canonical length: 242 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>P20396|TRH
     1  MPGPWLLLAL ALTLNLTGVP GGRAQPEAAQ QEAVTAAEHP GLDDFLRQVE RLLFLRENIQ
    61  RLQGDQGEHS ASQIFQSDWL SKRQHPGKRE EEEEEGVEEE EEEEGGAVGP HKRQHPGRRE
   121  DEASWSVDVT QHKRQHPGRR SPWLAYAVPK RQHPGRRLAD PKAQRSWEEE EEEEEREEDL
   181  MPEKRQHPGK RALGGPCGPQ GAYGQAGLLL GLLDDLSRSQ GAEEKRQHPG RRAAWVREPL
   241  EE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 63 nTPM
retina: 33 nTPM
cervix: 25 nTPM
endometrium: 18 nTPM
ovary: 4 nTPM
bone marrow: 3.5 nTPM

Single-cell type

müller glia: 257 nCPM
other brain neurons: 41 nCPM
retinal amacrine cells: 35 nCPM
endometrial glandular cells: 16 nCPM
early spermatids: 8.8 nCPM
cdc: 6.1 nCPM

Immune cell

intermediate monocyte: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 139 nTPM
medulla oblongata: 131 nTPM
pons: 83 nTPM
midbrain: 20 nTPM
basal ganglia: 10 nTPM
spinal cord: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: -0.23
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

thyrotropin-releasing hormone activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Thyrotropin-releasing hormone
Thyrotropin-releasing hormone (TRH)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRH as an antibody target. Whether an autoantibody or antibody against TRH could matter depends on whether native TRH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRH is annotated as secreted, so native TRH circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TRH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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