Seroatlas · Human Serome Atlas

TRGV9

T cell receptor gamma variable 9

Also known as: TCRGV9, TRGV9_HUMAN, V2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99603
Gene
TRGV9
Ensembl
ENSG00000211695
Chromosome
7
Canonical length
122 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable MHC protein binding activity and peptide antigen binding activity. Predicted to be involved in adaptive immune response and innate immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>Q99603|TRGV9
     1  MLSLLHTSTL AVLGALCVYG AGHLEQPQIS STKTLSKTAR LECVVSGITI SATSVYWYRE
    61  RPGEVIQFLV SISYDGTVRK ESGIPSGKFE VDRIPETSTS TLTIHNVEKQ DIATYYCALW
   121  EV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRGV9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
5.1 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 5.1 nTPM
  • placenta: 1.8 nTPM
  • spleen: 1.5 nTPM
  • thymus: 1.4 nTPM
  • bone marrow: 1 nTPM
  • retina: 0.7 nTPM

Single-cell type

  • nk-cells: 25 nCPM
  • innate lymphoid cells: 14 nCPM
  • t-cells: 6.3 nCPM
  • thymocytes: 5.9 nCPM
  • prostatic glandular cells: 1.2 nCPM
  • pdcs: 0.6 nCPM

Immune cell

  • gdT-cell: 427 nTPM
  • total PBMC: 39 nTPM
  • NK-cell: 33 nTPM
  • MAIT T-cell: 29 nTPM
  • memory CD8 T-cell: 20 nTPM
  • naive CD8 T-cell: 8.4 nTPM

Brain region

  • white matter: 1.8 nTPM
  • basal ganglia: 1.6 nTPM
  • pons: 1.5 nTPM
  • medulla oblongata: 1.4 nTPM
  • cerebral cortex: 1.2 nTPM
  • thalamus: 1.2 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRGV9 as an antibody target. Whether an autoantibody or antibody against TRGV9 could matter depends on whether native TRGV9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRGV9 is annotated at the cell surface, where native TRGV9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRGV9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRGV9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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