TRGV2
T cell receptor gamma variable 2
Also known as: TCRGV2, TRGV2_HUMAN, VIS2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6R0
- Gene
- TRGV2
- Ensembl
- ENSG00000233306
- Chromosome
- 7
- Canonical length
- 118 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in adaptive immune response and innate immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
118 residues, UniProt reviewed canonical sequence.
>A0A075B6R0|TRGV2
1 MQWALAVLLA FLSPASQKSS NLEGRTKSVI RQTGSSAEIT CDLAEGSNGY IHWYLHQEGK
61 APQRLQYYDS YNSKVVLESG VSPGKYYTYA STRNNLRLIL RNLIENDFGV YYCATWDGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRGV2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 6.2 nTPM
Expression across tissuesHPA
Tissue
- spleen: 6.2 nTPM
- lymph node: 4.6 nTPM
- thymus: 4.4 nTPM
- appendix: 1.5 nTPM
- small intestine: 1.3 nTPM
- prostate: 1.2 nTPM
Single-cell type
- t-cells: 5.7 nCPM
- nk-cells: 1.9 nCPM
- cardiomyocytes: 0.3 nCPM
- macrophages: 0.2 nCPM
- corticotrophs: 0.1 nCPM
- differentiating spermatogonia: 0.1 nCPM
Immune cell
- memory CD8 T-cell: 148 nTPM
- gdT-cell: 60 nTPM
- MAIT T-cell: 59 nTPM
- naive CD8 T-cell: 55 nTPM
- memory CD4 T-cell: 30 nTPM
- total PBMC: 22 nTPM
Brain region
- medulla oblongata: 2 nTPM
- midbrain: 1.4 nTPM
- thalamus: 1.3 nTPM
- white matter: 0.9 nTPM
- choroid plexus: 0.8 nTPM
- pons: 0.8 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRGV2 as an antibody target. Whether an autoantibody or antibody against TRGV2 could matter depends on whether native TRGV2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRGV2 is annotated at the cell surface, where native TRGV2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRGV2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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